Joanna Loch

Adjunct (Assistant professor)

Jagiellonian University

Poland

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Dr. Joanna Loch is an Adjunct Assistant Professor at Jagiellonian University in Poland. Her research focuses on the enzymatic activity and structural analysis of L-asparaginases, with recent articles exploring mutagenesis, protein packing, and therapeutic applications in leukemia. She investigates the biochemical characteristics of bacterial enzymes and their implications for cancer treatment, contributing to the understanding of enzyme mechanisms and substrate affinity.

Articles (20)

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Collaborators (13)

Katarzyna Kurpiewska

Assistant Professor with Habilitation

Gdańsk University of Technology, Faculty of Chemistry

POLAND

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Marcin Surmiak

Jagiellonian University Medical College

POLAND

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Piotr Bonarek

Jagiellonian University

POLAND

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Ivan Shabalin

Assistant Professor of Research

University of Virginia

UNITED STATES

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Andrzej Zielezinski

Assistant Professor

Adam Mickiewicz University in Poznań

POLAND

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Magdalena Wujak

Adjunct (Assistant Professor)

Nicolaus Copernicus University

POLAND

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Krzysztof Lewandowski

Poznan University of Medical Sciences

POLAND

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Miroslaw Gilski

Adam Mickiewicz University in Poznań

POLAND

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Magdalena Bejger

Institute of Bioorganic Chemistry Polish Academy of Sciences

POLAND

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Mariusz Jaskolski

Instytut Biopolimerow i Wlokien Chemicznych

POLAND

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Milosz Ruszkowski

Institute of Bioorganic Chemistry Polish Academy of Sciences

POLAND

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Krzysztof Brzezinski

Polska Akademia Nauk Instytut Chemii Bioorganicznej

POLAND

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Andrzej Wojtczak

Prof.

Nicolaus Copernicus University

POLAND

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Joanna Loch

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About

Articles (20)

Probing the Active Site of Class 3 L-Asparaginase by Mutagenesis: Mutations of the Ser-Lys Tandems of ReAV

Inotuzumab therapy resulted in molecular remission of relapsed/resistant B-cell acute lymphoblastic leukemia with BCR::ABL1 Lys404Glu mutation

Unique double-helical packing of protein molecules in the crystal of potassium-independent L-asparaginase from common bean

Controlling enzyme activity by mutagenesis and metal exchange to obtain crystal structures of stable substrate complexes of Class 3 <scp>l</scp>‐asparaginase

Substrate Affinity Is Not Crucial for Therapeutic L-Asparaginases: Antileukemic Activity of Novel Bacterial Enzymes

Probing the enzymatic activity and maturation process of the EcAIII Ntn-amidohydrolase using local random mutagenesis

Waterless structures in the Protein Data Bank

Probing the enzymatic activity and maturation process of the EcAIII Ntn-amidohydrolase using local random mutagenesis

Biochemical characterization of L-asparaginase isoforms from <i>Rhizobium etli</i>-the boosting effect of zinc

Probing the active site of Class 3 L-asparaginase by mutagenesis. I. Tinkering with the zinc coordination site of ReAV

β‐Lactoglobulin variants as potential carriers of pramoxine: Comprehensive structural and biophysical studies

The effects of nature‐inspired amino acid substitutions on structural and biochemical properties of the E. coli L‐asparaginase EcAIII

Rhizobium etli has two L-asparaginases with low sequence identity but similar structure and catalytic center

New ligand-binding sites identified in the crystal structures of β-lactoglobulin complexes with desipramine.

Structural and biophysical studies of new <scp>L</scp>-asparaginase variants: lessons from random mutagenesis of the prototypic <i>Escherichia coli</i> Ntn-amidohydrolase

Massive annotation of bacterial l-asparaginases reveals their puzzling distribution and frequent gene transfer events

Probing the ligand-binding pocket of recombinant β-lactoglobulin: Calorimetric and spectroscopic studies

Assessing the Interactions of Statins with Human Adenylate Kinase Isoenzyme 1: Fluorescence and Enzyme Kinetic Studies

Crystal structures of the elusive Rhizobium etli l-asparaginase reveal a peculiar active site

Structural and biophysical aspects of L-asparaginases: a growing family with amazing diversity

Collaborators (13)

Katarzyna Kurpiewska

Marcin Surmiak

Piotr Bonarek

Ivan Shabalin

Andrzej Zielezinski

Magdalena Wujak

Krzysztof Lewandowski

Miroslaw Gilski

Magdalena Bejger

Mariusz Jaskolski

Milosz Ruszkowski

Krzysztof Brzezinski

Andrzej Wojtczak

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