Joanne Lysaght

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Professor

Trinity College Dublin

Ireland

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About

Joanne Lysaght is a Professor at Trinity College Dublin, Ireland. Her research areas focus on the intersection of cancer therapies and immune responses, with recent articles exploring the effects of obesity on treatment efficacy, radiotherapy's role in T cell functionality, and the implications of histone deacetylase inhibitors in cancer therapy. Additionally, she examines the immune microenvironment in oesophageal adenocarcinoma and glioblastoma, highlighting factors that influence T cell behavior and therapeutic outcomes.

Recent Grants

Grant: Close

Evaluating the role of T cells in the progression of Barrett’s Oesophagus to OAC: identification of novel immunotherapeutic targets

Open Date: 2012-10-01

Close Date: 2015-09-01

Grant: Close

Investigating the role of T cells in adipose tissue and hepatic inflammation in obesity associated cancer

Open Date: 2011-10-01

Close Date: 2014-09-01

Grant: Close

Investigating the immunomodulatory effects of adipose tissue in oesophageal and colorectal cancer.

Open Date: 2009-10-01

Close Date: 2012-09-01

Grant: Close

Enhancing anti-tumour immunity in Oesophageal cancer through the modulation of immunometabolism with the novel small molecule inhibitor Quininib and its analogues

Open Date:

Close Date:

Grant: Close

. Elucidating the pathological role of obesity, inflammation and immunity in cancer related sarcopenia in upper gastrointestinal cancers.

Open Date:

Close Date:

Articles (12)

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2024

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2024

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2023

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2023

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

Collaborators (5)

Niamh Lynam-Lennon

Research Assistant Professor

Trinity College Dublin

IRELAND

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Noel E Donlon

Trinity College Dublin

IRELAND

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Stephen G. Maher

Trinity College Dublin

IRELAND

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Margaret Dunne

Assistant Lecturer

Technological University Dublin

IRELAND

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Stephen Finn

Associate Professor

Trinity College Dublin School of Medicine

IRELAND

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Joanne Lysaght

Research Interests

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About

Recent Grants

Articles (12)

The multifactorial effect of obesity on the effectiveness and outcomes of cancer therapies

Analysing the Combined Effects of Radiotherapy and Chemokine Receptor 5 Antagonism: Complementary Approaches to Promote T Cell Function and Migration in Oesophageal Adenocarcinoma

Acidosis significantly alters immune checkpoint expression profiles of T cells from oesophageal adenocarcinoma patients

PD-1 blockade attenuates surgery-mediated immunosuppression and boosts Th1 immunity perioperatively in oesophagogastric junctional adenocarcinoma.

The impact of histone deacetylase inhibitors on immune cells and implications for cancer therapy

Visceral adipose tissue secretome from early and late-stage oesophageal cancer patients differentially affects effector and regulatory T cells.

Investigating the Effects of Olaparib on the Susceptibility of Glioblastoma Multiforme Tumour Cells to Natural Killer Cell-Mediated Responses

Measuring Immune Cell Movement Toward the Soluble Microenvironment of Human Tissues Using a Boyden Chamber-Based Migration Assay.

Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma

Nutrient deprivation and hypoxia alter T cell immune checkpoint expression: potential impact for immunotherapy.

Incidence and Impact of Non-alcoholic Fatty Liver Disease (NAFLD) in Patients with Adenocarcinoma of the Esophagus Treated with Curative Intent.

The immune response to major gastrointestinal cancer surgery and potential implications for adjuvant immunotherapy.

Collaborators (5)

Niamh Lynam-Lennon

Noel E Donlon

Stephen G. Maher

Margaret Dunne

Stephen Finn

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