Jochen Walter

Professor of Molecular Neurology

University of Bonn

Germany

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Jochen Walter is a Professor of Molecular Neurology at the University of Bonn, Germany. His research primarily focuses on the mechanisms of neurodegenerative diseases, with particular emphasis on the roles of various proteins in neuronal function and pathology. Recent publications explore the interactions between DAP12 and TREM2, the impact of presenilin deficiency on cholesterol accumulation, and the phosphorylation state's influence on intraneuronal sorting of amyloid-beta peptides.

Articles (8)

Year:

2024

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2024

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2023

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2021

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2021

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2020

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2020

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2020

Collaborators (6)

Ulrich Schweizer

Universitätsklinikum Bonn

GERMANY

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Meliha Karsak

University Medical Center Hamburg-Eppendorf

GERMANY

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Bettina Linnartz-Gerlach

Head of Office for Scientific Management

University of Bonn

GERMANY

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Hirokazu Yagi

Assistant Professor

Nagoya University

JAPAN

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Jun-ichi Furukawa

Nagoya University

JAPAN

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Dieter Lütjohann

GERMANY

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Jochen Walter

Research Interests

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Articles (8)

Presenilin Deficiency Results in Cellular Cholesterol Accumulation by Impairment of Protein Glycosylation and NPC1 Function

DAP12 interacts with RER1 and is retained in the secretory pathway before assembly with TREM2

Phosphorylation-state dependent intraneuronal sorting of Aβ differentially impairs autophagy and the endo-lysosomal system

Carboxy-terminal fragment of amyloid precursor protein mediates lipid droplet accumulation upon γ-secretase inhibition

A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease‐associated variants on receptor signaling and activation by antibodies against the stalk region

Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models

Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism

A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2

Collaborators (6)

Ulrich Schweizer

Meliha Karsak

Bettina Linnartz-Gerlach

Hirokazu Yagi

Jun-ichi Furukawa

Dieter Lütjohann

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