John C. Fortney

The PTSD Checklist for DSM‐5 (PCL‐5) is a measure of posttraumatic stress disorder (PTSD) symptom severity that is widely used for clinical and research purposes. Although previous work has examined metrics of minimal important difference (MID) of the PCL‐5 in veteran samples, no work has identified PCL‐5 MID metrics among adults in primary care in the United States. In this secondary analysis, data were evaluated from primary care patients ( N = 971) who screened positive for PTSD and participated in a large clinical trial in federally qualified health centers in three U.S. states. Participants primarily self‐identified as women (70.2%) and White (70.3%). We calculated test–retest reliability using clinic registry data and multiple distribution‐ and anchor‐based metrics of MID using baseline and follow‐up survey data. Test–retest reliability (Pearson's r , Spearman's ρ, intraclass correlation coefficient) ranged from adequate to excellent (.79–.94), with the shortest time lag demonstrating the highest reliability estimate. The MID for the PCL‐5 was estimated using multiple approaches. Distribution‐based approaches indicated an MID range of 8.5–12.5, and anchor‐based approaches indicated an MID range of 9.8–11.7. Taken together, the MID metrics indicate that PCL‐5 change scores of 9–12 likely reflect real change in PTSD symptoms and indicate at least an MID for patients, whereas PCL‐5 change scores of 5 or less likely are not reliable. These findings can help inform clinicians using the PCL‐5 in similar populations to track patient responses to treatment and help researchers interpret PCL‐5 score changes in clinical trials.