John Chang

Professor

University of California, San Diego

United States

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About

John Chang is a Professor at the University of California, San Diego. His research focuses on immunological responses and the role of T cells in various inflammatory diseases, particularly Crohn's disease and ulcerative colitis. Recent publications include analyses of cytokine antagonists, T cell differentiation mechanisms, and the interplay between the host immune system and microbiome under different therapeutic conditions.

Articles (11)

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2025

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2021

Collaborators (5)

Ananda W. Goldrath

UNITED STATES

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Derek Holman

Stanford University

UNITED STATES

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Yu Kato

La Jolla Institute for Immunology

UNITED STATES

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Christian M. Schürch

Professor

University Hospital Tübingen

GERMANY

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Stephan Rogalla

Stanford University School of Medicine

UNITED STATES

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John Chang

Research Interests

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About

Articles (11)

IL-23p19 Antagonists vs Ustekinumab for Treatment of Crohn's Disease: A Meta-Analysis of Randomized Controlled Trials

Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein DDX5

Identification of CD8+ T cell - immune cell communications in ileal Crohn's disease.

Early transcriptional and epigenetic divergence of CD8+ T cells responding to acute versus chronic infection.

A tissue atlas of ulcerative colitis revealing evidence of sex-dependent differences in disease-driving inflammatory cell types and resistance to TNF inhibitor therapy

Small intestine and colon tissue-resident memory CD8<sup>+</sup> T cells exhibit molecular heterogeneity and differential dependence on Eomes.

Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments

Preserved SARS-CoV-2 Vaccine Cell-Mediated Immunogenicity in Patients With Inflammatory Bowel Disease on Immune-Modulating Therapies.

The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis Patients.

RORγt phosphorylation protects against T cell-mediated inflammation.

Skin inflammation activates intestinal stromal fibroblasts and promotes colitis.

Collaborators (5)

Ananda W. Goldrath

Derek Holman

Yu Kato

Christian M. Schürch

Stephan Rogalla

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