John Chisholm

Professor

Syracuse University

United States

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Professor John Chisholm is currently a faculty member at Syracuse University in the United States. His research focuses on topics related to enzymatic inhibitors, particularly involving the SH2 domain‐containing inositol 5’‐phosphatase (SHIP), and their implications in microglial functions, cancer pathways, and obesity control. Recent works include studies on aminocholestane inhibitors, customized ligand-conjugate systems, and various catalytic reactions relevant to his fields of inquiry.

Articles (18)

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2025

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2024

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2024

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2022

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2022

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2022

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2022

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2022

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2022

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2022

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2021

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2021

Collaborators (5)

DIMITRA BOURBOULIA

SUNY Upstate Medical University

UNITED STATES

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Rosa Chiara Paolicelli

Assistant Professor

University of Lausanne

SWITZERLAND

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Jasmeen Oberoi

University of Sussex

UNITED KINGDOM

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William Kerr

Professor of Microbiology & Immunology

SUNY Upstate Medical University

UNITED STATES

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Mehdi Mollapour

Adjunct Professor

SUNY Upstate Medical University

UNITED STATES

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John Chisholm

Research Interests

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About

Articles (18)

Aminocholestane and Aminoandrostane Inhibitors of the SH2 Domain‐Containing Inositol 5’‐Phosphatase (SHIP)

A Modular Customizable Ligand-Conjugate (LC) System Targeting Ghrelin O-Acyltransferase

SHIP inhibition mediates select TREM2-induced microglial functions

Brønsted acid catalyzed N2‑selective alkylation of 1,2,3-triazoles with trichloroacetimidates

DDQ catalyzed oxidative lactonization of indole-3-butyric acids

Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment

Structure–Activity Studies on Bis-Sulfonamide SHIP1 Activators

SHIP1 inhibition via 3-alpha-amino-cholestane enhances protection against Leishmania infection

Catalytic inhibitor of Protein Phosphatase 5 activates the extrinsic apoptotic pathway by disrupting complex II in kidney cancer

N1-Benzyl Tryptamine Pan-SHIP1/2 Inhibitors: Synthesis and Preliminary Biological Evaluation as Anti-Tumor Agents

Tandem oxidation-bromination of allylic alcohols with a TEMPO-Oxone-Et4NBr reactant system

Acid Catalyzed N-Alkylation of Pyrazoles with Trichloroacetimidates

LRBA Deficiency Can Lead to Lethal Colitis That Is Diminished by SHIP1 Agonism

Discovery of a novel SHIP1 agonist that promotes degradation of lipid-laden phagocytic cargo by microglia

Alkylation of isatins with trichloroacetimidates

Synthetic studies on the indane SHIP1 agonist AQX-1125

Formation of pyrroloindolines via the alkylation of tryptamines with trichloroacetimidates

Metal Free Amino‐Oxidation of Electron Rich Alkenes Mediated by an Oxoammonium Salt

Collaborators (5)

DIMITRA BOURBOULIA

Rosa Chiara Paolicelli

Jasmeen Oberoi

William Kerr

Mehdi Mollapour

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