John Falck

Professor

University of Texas Southwestern Medical School

United States

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Professor John Falck is a faculty member at the University of Texas Southwestern Medical School, located in the United States. His research primarily focuses on the role of epoxyeicosatrienoic acids, renal physiology, and the mechanisms of hypertension. Recent articles highlight his work on dual acting inhibitors and their effects on glomerular injury, as well as the impact of EET therapy on congestive heart failure and nephrotoxicity.

Articles (13)

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2025

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2025

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2024

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2023

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2020

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2020

Collaborators (6)

Janusz Sadowski

Professor

Polish Academy of Sciences

POLAND

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Thomas J Masi

Assistant Professor

University of Tennessee Medical Center

UNITED STATES

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Md Abdul Hye Khan

Assistant Professor

Medical College of Wisconsin

UNITED STATES

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Matúš Miklovič

Institute of Experimental Medicine

CZECH REPUBLIC

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Ling Zhao

Professor

University of Tennessee

UNITED STATES

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John Imig

University of Arkansas for Medical Sciences

UNITED STATES

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John Falck

Research Interests

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Articles (13)

Dual acting inhibitor of soluble epoxide hydrolase and Cyclooxygenase-2, attenuates glomerular injury in renal hypoplasia mice

Epoxyeicosatrienoic acids (EETs): A novel class of second messengers of hormonal functional responses

Effects of 17,18-EEQ analog (TZ-1) on brown adipogenesis and browning of human adipose-derived stromal cells

Effect of Chronically Suppressed Plasma Angiotensin II on Regulation of the CYP4A/20-HETE Pathway in the Dahl Salt-Sensitive Rat

Directed, Remote Dirhodium C(sp3)-H Functionalization, Desaturative Annulation, and Desaturation

Macrophage 12(S)-HETE Enhances Angiotensin II–Induced Contraction by a BLT2 (Leukotriene B 4 Type-2 Receptor) and TP (Thromboxane Receptor)-Mediated Mechanism in Murine Arteries

Site-selective amination and/or nitrilation via metal-free C(sp2)–C(sp3) cleavage of benzylic and allylic alcohols

Novel Synthetic Analogues of 19(S/R)-Hydroxyeicosatetraenoic Acid Exhibit Noncompetitive Inhibitory Effect on the Activity of Cytochrome P450 1A1 and 1B1

Effects of Epoxyeicosatrienoic Acid-Enhancing Therapy on the Course of Congestive Heart Failure in Angiotensin II-Dependent Rat Hypertension: From mRNA Analysis towards Functional In Vivo Evaluation

Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity

Intramolecular N–Me and N–H aminoetherification for the synthesis of N-unprotected 3-amino-O-heterocycles

A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of the Sirtuin 3–NLRP3 Pathway

Picolinate-Directed Arene meta-C–H Amination via FeCl3 Catalysis

Collaborators (6)

Janusz Sadowski

Thomas J Masi

Md Abdul Hye Khan

Matúš Miklovič

Ling Zhao

John Imig

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