John Lazo

Professor

University of Virginia

United States

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John Lazo is a Professor at the University of Virginia, USA. His research areas include the pharmacological targeting of protein tyrosine phosphatases, specifically PTP4A3, in cancer therapy and drug development for viral infections. Recent publications highlight his work on inhibitors of SARS-CoV-2 and HIV-1, as well as studies on tumorigenicity in ovarian cancer cells.

Articles (8)

Year:

2024

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2024

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2024

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2023

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2023

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2023

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2021

Year:

2020

Collaborators (4)

Ettore Rastelli

University of Pittsburgh

UNITED STATES

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Peter Wipf

Distinguished University Professor

University of Pittsburgh

UNITED STATES

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Pavel Solopov

Research Assistant Professor

Old Dominion University

UNITED STATES

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Ruben Manuel Luciano Colunga Biancatelli

Research Assistant Professor

Old Dominion University

UNITED STATES

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John Lazo

Research Interests

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Articles (8)

KVX-053, a Protein Tyrosine Phosphatase 4A3 inhibitor, ameliorates SARS‐CoV‐2 Spike protein subunit 1 - induced acute lung injury in mice

Discovery of Benzisothiazolone Derivatives as Bifunctional Inhibitors of HIV-1 Reverse Transcriptase DNA Polymerase and Ribonuclease H Activities

Deletion of PTP4A3 phosphatase in high grade serous ovarian cancer cells decreases tumorigenicity and produces marked changes in intracellular signaling pathways and cytokine release.

An acute respiratory distress syndrome drug development collaboration stimulated by the Virginia Drug Discovery Consortium

High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons

Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase

Credentialing and Pharmacologically Targeting PTP4A3 Phosphatase as a Molecular Target for Ovarian Cancer

Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production

Collaborators (4)

Ettore Rastelli

Peter Wipf

Pavel Solopov

Ruben Manuel Luciano Colunga Biancatelli

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