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John R. Lukens

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University of Virginia

United States

Research Interests

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Professors in United States Professors in Immunology Immunology professors in United States

Recent Grants

Grant: Close

Delineating the effects of sex on microglia in neurodevelopmental disorders

Open Date: 2019-06-11

Close Date: 2021-03-31

Grant: Close

Inflammasome activation and lymphatic dysfunction in traumatic brain injury

Open Date: 2018-09-15

Close Date: 2023-07-31

Grant: Close

Lymphatic Dysfunction and Inflammasomes as Drivers Alzheimer's Disease Pathology

Open Date: 2018-01-01

Close Date:

Articles (31)

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Collaborators (7)

Jeff Dupree

Associate Professor

Virginia Commonwealth University

UNITED STATES

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Tajie H Harris

Associate Professor

University of Virginia

UNITED STATES

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Brian Delisle

Professor

University of Kentucky

UNITED STATES

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Jayakrishna Ambati

Professor & Vice Chair for Research

University of Virginia

UNITED STATES

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Catherine Gorick

University of Virginia

UNITED STATES

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SHAOBIN WANG

Assistant Professor

University of Virginia

UNITED STATES

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Richard Price

Professor

University of Virginia

UNITED STATES

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John R. Lukens

Research Interests

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Recent Grants

Articles (31)

The nucleoside analog kamuvudine-9 shows protective and therapeutic efficacy in a mouse model of multiple sclerosis

Microglial ITAM & ITIM Signaling in Neurodegenerative Disease and Brain Aging

Wolf in sheep’s clothing: leveraging sheep to study how maternal immune activation contributes to neurodevelopmental disorders

The Genotoxic Stress Sensor ZBP1 Drives Tau Pathology

Computational Fluid Dynamic Model Prediction of Enhanced Glymphatic Clearance in Response to Focused Ultrasound‐Mediated Blood‐Brain Barrier Opening

Taking the STING out of neurodegenerative disease

Emerging roles for innate and adaptive immunity in tauopathies

Peripheral infection wires T cells in the brain

Harnessing microglia-based cell therapies for the treatment of neurodegenerative diseases

On-demand microglia deliver the therapeutic payload in Alzheimer’s disease

STING deletion protects against amyloid β–induced Alzheimer's disease pathogenesis

Glia get RIPped in ALS

Myelin debris as an initiator of microglial dysfunction and neuropathology in Alzheimer’s disease

Role of inflammasomes and neuroinflammation in epilepsy

Focused ultrasound-microbubble treatment arrests the growth and formation of cerebral cavernous malformations

Caspase-8 expression in CD8+ T cells promotes pathogen restriction in the brain during Toxoplasma gondii infection

Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease

Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis

Inflammasome signaling in astrocytes modulates hippocampal plasticity

Microglia pack a toolbox for life

The Alzheimer's disease risk factor <i>INPP5D</i> restricts neuroprotective microglial responses in amyloid beta‐mediated pathology

CARD9 attenuates Aβ pathology and modifies microglial responses in an Alzheimer’s disease mouse model

The innate immune response in tauopathies

Misguided antibodies change the course of brain development

Engineering mighty microglia

Role of the caspase-8/RIPK3 axis in Alzheimer’s disease pathogenesis and Aβ-induced NLRP3 inflammasome activation

The meningeal transcriptional response to traumatic brain injury and aging

Microglia rely on SYK signalling to mount neuroprotective responses in models of Alzheimer's disease and multiple sclerosis

Emerging roles for ITAM and ITIM receptor signaling in microglial biology and Alzheimer's disease‐related amyloidosis

The nervous system during COVID‐19: Caught in the crossfire

How neurons die in Alzheimer's disease: Implications for neuroinflammation

Collaborators (7)

Jeff Dupree

Tajie H Harris

Brian Delisle

Jayakrishna Ambati

Catherine Gorick

SHAOBIN WANG

Richard Price

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