Joëlle Rüegg

Uppsala University’s Molecular Toxicology and Epigenetics (EpiTox) group is recruiting for both a PhD studentship in circadian epigenomics and a postdoctoral position in epigenomic data analysis. The research focuses on understanding how DNA methylation patterns are regulated across the circadian cycle and the role of epigenetic mechanisms in neurodevelopmental effects of environmental chemicals. The EpiTox group is part of the Department of Organismal Biology and the Physiology and Environmental Toxicology research program, providing a vibrant, international, and interdisciplinary environment. The PhD project, funded by the Swedish Research Council (VR), investigates circadian regulation of DNA methylation and its implications for neurodevelopment. The successful candidate will work primarily in the wet lab, performing mammalian cell culture, DNA/RNA extraction, CRISPR-based tagging, and bioinformatic analyses (DNA methylation and RNA-seq) using R or Python. The project includes collaboration with Dr. Philipp Antczak (University of Cologne) for bioinformatics. Applicants must have a Master’s degree in molecular biology, cell biology, or a related field, experience with molecular biology methods, and strong English skills. Additional experience with cell culture, CRISPR, and bioinformatics is advantageous. The postdoctoral position, funded by the Formas EpiDNT project, focuses on bioinformatic and biostatistical analysis of epigenomic datasets from both cellular models and human samples, including Oxford Nanopore and Illumina EPIC data. The postdoc will also conduct literature reviews and meta-analyses to identify epigenomic markers of chemically induced neurodevelopmental effects. Collaboration with Professor Carl-Gustaf Bornehag (Karlstad University) is included. Applicants must have a PhD in bioinformatics, biostatistics, computational biology, or a similar field, with experience in R or Python, long-read sequencing, DNA methylation data analysis, and environmental epigenomics. Excellent English communication skills and the ability to work independently and collaboratively are required. Both positions are fully funded, full-time, and offer competitive salaries and benefits. The PhD position is a temporary appointment as per Swedish Higher Education Ordinance, and the postdoc is a 2-year contract with a possible 1-year extension. The application deadline for both positions is January 30, 2026. Uppsala University is committed to providing a supportive and inclusive work environment for its 7,600 employees and 53,000 students. For more information and to apply, visit the provided application links. For specific questions, contact Professor Joëlle Rüegg at [email protected].

The Molecular Toxicology and Epigenetics (EpiTox) group at Uppsala University, led by Professor Joëlle Rüegg, is recruiting a postdoctoral researcher in bioinformatics and a PhD student in molecular biology. The group investigates the role of epigenetic mechanisms in neurodevelopmental effects of environmental chemicals and the influence of circadian rhythms on epigenetic patterns and toxic responses. Research is conducted within a vibrant, international environment at the Department of Organismal Biology, with strong collaborations including Karlstad University and the University of Cologne. The postdoctoral position focuses on epigenetic data analysis, particularly bioinformatic and biostatistical analyses of epigenomic datasets generated by Oxford Nanopore sequencing and Illumina EPIC arrays. The project, funded by Formas, aims to identify epigenetic markers for exposure-related health effects in humans, with a special emphasis on neurodevelopment. The postdoc will also conduct literature reviews and meta-analyses, contribute to scientific publications, and participate in group and departmental activities. Applicants must have a recent doctoral degree in bioinformatics, biostatistics, computational biology, or a related field, with strong skills in R or Python, experience in long-read sequencing and DNA methylation data analysis, and excellent English communication abilities. The PhD position, embedded in a VR-funded project, investigates how DNA methylation patterns are regulated across the circadian cycle. The student will primarily work in the wet lab, performing mammalian cell culture, molecular biology methods, and CRISPR-based tagging, as well as learning bioinformatic analyses of DNA methylation and RNA-seq datasets. Applicants must hold a Master’s degree or equivalent in molecular biology, cell biology, or a related field, with experience in molecular biology methods and proficiency in English. Additional qualifications include experience with mammalian cell culture, CRISPR/Cas9, and bioinformatics. Both positions are fully funded, with the postdoc offered a 2-year contract (possible 1-year extension) and the PhD a full-time, fixed-salary appointment. Uppsala University provides a supportive, international research environment with comprehensive employment benefits. The application deadline for both positions is January 30, 2026. For more information and to apply, visit the provided links or contact Professor Joëlle Rüegg at [email protected].

Uppsala University is inviting applications for a fully funded PhD position in Circadian Epigenomics within the Department of Organismal Biology (EpiTox group). The research focuses on understanding how DNA methylation patterns shift across the circadian cycle, combining wet-lab molecular biology (mammalian cell culture, CRISPR tagging, DNA/RNA extraction) with bioinformatics analyses (R/Python, DNA methylation, RNA-seq). The project is embedded in a VR-funded initiative and involves collaboration with the University of Cologne, where Dr. Philipp Antczak will co-supervise bioinformatics aspects. The EpiTox group investigates epigenetic mechanisms in neurodevelopmental effects of environmental chemicals and circadian regulation. The research environment is international, vibrant, and supportive, offering opportunities to engage in scientific and social activities at the group, program, and departmental levels. The successful candidate will plan, perform, analyze, and interpret experiments, communicate research findings, and may advise master and bachelor students. Applicants must have a Master’s degree in molecular biology, cell biology, or a related field, or equivalent higher education. Required skills include experience with molecular biology methods and strong English communication abilities. Additional assets are experience with mammalian cell culture, CRISPR/Cas9, and bioinformatics (especially DNA methylation and RNA-seq). Background knowledge in epigenetics or circadian regulation is a plus. The position values motivation, creativity, analytical thinking, independence, and teamwork. The PhD position is a full-time, salaried employment under the Swedish model, with favorable working conditions and no tuition fees. The application deadline is January 30, 2026. For more information, contact Professor Joëlle Rüegg ([email protected]). Apply through Uppsala University's recruitment system using the provided link. Keywords: circadian epigenomics, DNA methylation, molecular biology, cell biology, epigenetics, bioinformatics, CRISPR, mammalian cell culture, RNA-seq, EpiTox, toxicology