Jonas Stenløkke Madsen

This full-time postdoctoral position is based in the Social Systems Microbiology research group at the Section of Microbiology, Department of Biology, University of Copenhagen . The project is centered on developing and applying single-cell transcriptomic and genomic approaches to prokaryotes, with a particular emphasis on bacteria and archaea and on protocols for capturing extrachromosomal elements and their transcripts. The postdoc will work on a method-driven, exploratory basic research project addressing phenotypic heterogeneity in microorganisms —specifically, why genetically identical cells can form distinct phenotypic subpopulations and what mechanisms generate this diversity. The work combines wet-lab protocol development with sequencing and downstream data analysis, with scope to adapt and refine approaches across a diverse set of microbial systems. Research activities include cultivating bacteria and archaea, developing and optimising methods for isolating and sequencing extrachromosomal DNA and associated transcripts, applying single-cell omics strategies to prokaryotes, and quantifying DNA and RNA using qPCR and digital PCR alongside bulk DNA and RNA sequencing. The role also includes analysing sequencing data, publishing results, and contributing to the scientific life of the group. The position is embedded in an international and collaborative microbiology environment with access to state-of-the-art facilities. The group studies the molecular biology, ecology and evolution of bacterial interactions and offers a supportive setting where ideas are shared openly and researchers are encouraged to develop their own research directions. The position is supervised by Associate Professor Jonas Stenløkke Madsen .