Jonathan Higgins

Professor of Eukaryotic Molecular Cell Biology

Newcastle University

United Kingdom

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Jonathan Higgins is a Professor of Eukaryotic Molecular Cell Biology at Newcastle University in the United Kingdom. His research focuses on protein kinase signaling networks, histone phosphorylation during mitosis, and cellular mechanics. Recent publications include studies on transcription factors in mitosis, the role of PCTAIRE1 in mitotic progression, and mechanisms of DNA replication in cancer cells.

Articles (12)

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2020

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Harvard University

UNITED STATES

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Jonathan Higgins

Research Interests

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Articles (12)

Release of Histone H3K4-reading transcription factors from chromosomes in mitosis is independent of adjacent H3 phosphorylation.

Pharmacological approaches to understanding protein kinase signaling networks

Acute brain slice elastic modulus decreases over time

Simultaneous Measurement of Single-Cell Mechanics and Cell-to-Materials Adhesion Using Fluidic Force Microscopy

Robustness of NanoBiT luciferase complementation technology in the presence of widely used kinase inhibitors

Dissecting the roles of Haspin and VRK1 in histone H3 phosphorylation during mitosis

PCTAIRE1 promotes mitotic progression and resistance against antimitotic and apoptotic signals

The Aurora B gradient sustains kinetochore stability in anaphase

A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes

Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability

Kinase inhibition profiles as a tool to identify kinases for specific phosphorylation sites

Priming chromatin for segregation: functional roles of mitotic histone modifications

Collaborators (6)

Emmanouil Papamichos-Chronakis

jinju chen

Daniel Rico

Luke Gaughan

Urszula McClurg

Thomas Roberts

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