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Jonathan Karn

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Professor and Chair

Case Western Reserve University

United States

Research Interests

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Recent Grants

Grant: Open

The impact of poly-substance use on the crosstalk between microglia, astrocytes, and neurons that regulates HIV latency

Open Date: 2024-05-15

Close Date: 2029-02-28

Grant: Open

Sex-differences in HIV persistence and Immune Dynamics during Reproductive Aging

Open Date: 2023-09-22

Close Date: 2028-07-31

Grant: Open

Nuclear receptor regulation of epigenetic mechanisms regulating HIV CNS latency

Open Date: 2023-08-01

Close Date: 2028-05-31

Grant: Close

Innate and adaptive defenses against SARS-COV-2 in the oral cavity during acute unvaccinated and breakthrough infections

Open Date: 2022-09-01

Close Date: 2024-08-31

Grant: Close

The role of RNA m6A modification in the regulation of HIV latency and reactivation

Open Date: 2022-04-01

Close Date: 2025-03-31

Articles (16)

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2023

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UNITED STATES

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Mariana Gerschenson

Professor

University of Hawaii at Manoa

UNITED STATES

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Group leader

University Hospital Heidelberg

GERMANY

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Jonathan Karn

Research Interests

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Recent Grants

Articles (16)

Reduction of the HIV-1 reservoir in T cells from people with HIV-1 on suppressive antiretroviral therapy using expanded natural killer cells

Non-neutralizing antibodies against SARS-CoV-2 nucleocapsid protein mediate variant transcendent antibody-dependent cellular cytotoxicity

Interleukin-2 is a potent latency reversal agent in people with treated HIV-1

HIV infection reprogrammes CD4+ T cells for quiescence and entry into proviral latency

Cytokine trajectory over time in men and women with HIV on long-term ART

Direct Analysis of HIV mRNA m<sup>6</sup>A Methylation by Nanopore Sequencing

Protocol for intracellular immunofluorescence measurements of latent HIV reactivation in a primary CD4<sup>+</sup> T cell model

Structural rearrangements in the nucleus localize latent HIV proviruses to a perinucleolar compartment supportive of reactivation

The cell biology of HIV-1 latency and rebound

The sounds of silencing: Dynamic epigenetic control of HIV latency

Contemporary Antiretroviral Therapy Dysregulates Iron Transport and Augments Mitochondrial Dysfunction in HIV-Infected Human Microglia and Neural-Lineage Cells

Genomic profiling of HIV-1 integration in microglia cells links viral integration to the topologically associated domains.

A viral pan-end RNA element and host complex define a SARS-CoV-2 regulon

3D human tissue models and microphysiological systems for HIV and related comorbidities

Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary.

New insights into transcription elongation control of HIV-1 latency and rebound

Collaborators (14)

Robert Furler O'Brien

Xinlian Zhang

Mary Kearney

Jürgen Bosch

Daniel Blankenberg

Mariana Gerschenson

Asha Kallianpur

Iart Luca Shytaj

Christopher King

Scott Sieg

GuanQun Liu

Kyung Sung

George A Yendewa

Marina Lusic

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