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Jonathan Richard

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Rechearch Scientist

Université de Montréal

Canada

Research Interests

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Professors in Canada Professors in Immunology Immunology professors in Canada

Recent Grants

Grant: Open

The RESTART Trial: Reducing Systemic inflammation for people on AntiRetroviral Therapy.

Open Date: 2024-06-01

Close Date: 2028-05-31

Grant: Close

Closing the Comorbidity Gap for People Living with HIV : a Randomized Controlled Trial of Fostemsavir to Reduce Inflammaging

Open Date: 2023-09-01

Close Date: 2024-08-31

Grant: Close

Harnessing NK cell responses to eliminate HIV-1-infected cells

Open Date: 2017-10-01

Close Date: 2019-10-01

Grant: Close

Harnessing ADCC responses to eliminate HIV-1-infected cells

Open Date: 2016-07-01

Close Date: 2017-06-01

Grant: Close

Identification of broadly-neutralizing antibodies targeting HIV-1 envelope glycoproteins in their unbound conformation.

Open Date: 2014-04-01

Close Date: 2017-03-31

Articles (18)

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Collaborators (21)

Julia Niessl

Karolinska Institutet

SWEDEN

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Sylvie Trottier

Professeur associée

Laval University

CANADA

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Doreen Matthies

Earl Stadtman Tenure Track Investigator

National Institutes of Health

UNITED STATES

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Mohamed El-Far

Senior Research Associate

Centre de recherche du CHUM

CANADA

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Andrés Finzi

Full Professor

Université de Montréal

CANADA

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Wenwei Li

Associate Research Scientist

Yale University

UNITED STATES

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Janet Cunningham

Senior Clinical Lecturer in Psychiatry and Consultant Psychiatrist

Uppsala University

SWEDEN

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Tommaso Clemente

Ospedale San Raffaele

ITALY

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Jean-Pierre Routy

Professor

McGill University Health Centre

CANADA

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Madeleine Durand

Full Clinical Professor

Université de Montréal

CANADA

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Carl Chartrand-Lefebvre

Directeur

Université de Montréal

CANADA

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Daniel Lee

Assistant Professor

University of Northern Iowa

UNITED STATES

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Daniel Elias Kaufmann

Chief, Division of Infectious Diseases

Lausanne University Hospital

SWITZERLAND

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Martine Tetreault

Associate Professor

Université de Montréal

CANADA

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Hugo Zeberg

Karolinska Institutet

SWEDEN

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Priti Kumar

Professor

Yale University

UNITED STATES

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Guy Wolf

Assistant Professor

Université de Montréal

CANADA

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Alexandra Tauzin

INSERM

FRANCE

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Frank Kirchhoff

Director

Ulm University Medical Center

GERMANY

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Alexandre Prat

Chairman

Université de Montréal

CANADA

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Marzena Pazgier

Professor

Uniformed Services University of the Health Sciences

UNITED STATES

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Jonathan Richard

Research Interests

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Recent Grants

Articles (18)

Fostemsavir Decreases the Levels of Anti-gp120 CD4-Induced Antibodies in Heavily Treatment-Experienced People With HIV

mGem: Opening Env and harnessing NK cell effector functions to eliminate HIV-1-infected cells

The HIV-1 envelope cytoplasmic tail protects infected cells from ADCC by downregulating CD4

The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC

Safety, pharmacokinetics, and biological activity of CD4-mimetic BNM-III-170 in SHIV-infected rhesus macaques

Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity

Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy–Treated Individuals With Undetectable Viremia

CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies.

NTB-A and 2B4 Natural Killer Cell Receptors Modulate the Capacity of a Cocktail of Non-Neutralizing Antibodies and a Small CD4-Mimetic to Eliminate HIV-1-Infected Cells by Antibody-Dependent Cellular Cytotoxicity

The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity

Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC

Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity

Excess BAFF May Impact HIV-1-Specific Antibodies and May Promote Polyclonal Responses Including Those from First-Line Marginal Zone B-Cell Populations

Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity

Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity

Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines

Temsavir Modulates HIV-1 Envelope Conformation by Decreasing Its Proteolytic Cleavage

Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120

Collaborators (21)

Julia Niessl

Sylvie Trottier

Doreen Matthies

Mohamed El-Far

Andrés Finzi

Wenwei Li

Janet Cunningham

Tommaso Clemente

Jean-Pierre Routy

Madeleine Durand

Carl Chartrand-Lefebvre

Daniel Lee

Daniel Elias Kaufmann

Martine Tetreault

Hugo Zeberg

Priti Kumar

Guy Wolf

Alexandra Tauzin

Frank Kirchhoff

Alexandre Prat

Marzena Pazgier

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