Jonathan Silva

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Associate Professor

Washington University in St. Louis

United States

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About

Jonathan Silva is an Associate Professor at Washington University in Saint Louis, USA. His research areas include cardiac ion channel function, specifically in relation to Nav1.5 channels, and the application of augmented reality in medical procedures. His recent articles focus on the regulatory mechanisms of cardiac sodium channels and innovative methods for modeling electrophysiology in cardiac cells.

Recent Grants

Grant: Open

Precision Antiarrhythmic Medicine: Using Biophysical Insight to Improve Therapy

Open Date: 2022-07-01

Close Date: 2027-06-30

Articles (12)

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2025

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2025

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2021

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2021

Collaborators (7)

Jennifer N Avari Silva

Washington University in St. Louis

UNITED STATES

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Nathaniel Huebsch

Assistant Professor

Washington University in St. Louis

UNITED STATES

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William Orr

Assistant Professor

Washington University Physicians

UNITED STATES

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Evan Miller

University of California, Berkeley

UNITED STATES

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Jagmeet Singh

Professor

Massachusetts General Hospital

UNITED STATES

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Cecilia Lindskog

SWEDEN

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Sharon Cresci

UNITED STATES

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Jonathan Silva

Research Interests

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About

Recent Grants

Articles (12)

Investigating the role of the I–II linker in Nav1.5 channel function

The PARADIGM Study: Procedural Augmented Reality Assessment in a 3-Dimensional Image-Guided Modality

Determinants of iFGF13-mediated regulation of myocardial voltage-gated sodium (NaV) channels in mouse

Differential regulation of cardiac sodium channels by intracellular fibroblast growth factors

Emerging methods to model cardiac ion channel and myocyte electrophysiology

Robust, Automated Analysis of Electrophysiology in Induced Pluripotent Stem Cell-Derived Micro-Heart Muscle for Drug Toxicity

An allosteric modulator activates BK channels by perturbing coupling between Ca2+ binding and pore opening

The Expanding Uses of Medical Extended Reality in the Cardiac Catheterization Laboratory: Pre-procedural Planning, Intraprocedural Guidance, and Intraprocedural Navigation

Early preclinical experience of a mixed reality ultrasound system with active GUIDance for NEedle-based interventions: The GUIDE study

Pulsus Alternans in Cardiogenic Shock Recapitulated in Single Cell Fluorescence Imaging of a Patient’s Cardiomyocyte

Conformations of voltage-sensing domain III differentially define NaV channel closed- and open-state inactivation

Identification of structures for ion channel kinetic models

Collaborators (7)

Jennifer N Avari Silva

Nathaniel Huebsch

William Orr

Evan Miller

Jagmeet Singh

Cecilia Lindskog

Sharon Cresci

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