José L. Mascareñas
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Recent Grants
Grant: Close
Selectively eliminating cancer stem cells through inhibition of mitochondrial respiration using metal-based small molecules
Open Date: 2022-01-01
Close Date: 2023-12-01
Grant: Close
Metal-based anticancer agents targeting the mitochondrial respiration of cancer stem cells
Open Date: 2021-12-01
Close Date: 2023-11-01
Grant: Close
Targeting the cancer stem cell (CSC) metabolism with designed, reactive metal complexes
Open Date: 2021-01-01
Close Date: 2022-06-01
Grant: Close
Convenio de Colaboración entre a Axencia Galega de Innovación, a Consellería de Cultura, Educación e Universidade, a USC e CSIC para fomentar a actividade Investigadora do persoal investigador finalista nas convocatorias de axudas do ERC no Marco do H2020
Open Date: 2021-01-01
Close Date: 2022-11-01
Grant: Close
Consolidación y estructuración de Unidades de Investigación Competitivas del SUG: modalidad grupos de referencia competitiva
Open Date: 2021-01-01
Close Date: 2024-11-01
Articles (11)
We report the modelling of the DNA complex of an artificial miniprotein composed of two zinc finger modules linked by an AT-hook peptide.
Year:
2023
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2023
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2023
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2023
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2023
Year:
2022
Pd 0 catalysts featuring phosphorus‐based monodentate ligands can detour the reactivity of carbonyl‐tethered alkylidenecyclopropanes (ACPs) from standard (3+2) cycloadditions towards tandem cycloisomerization/cross‐coupling processes. This new reactivity lies on the formation of key π‐allyl oxapalladacyclic intermediates, which are subsequently trapped with external nucleophilic partners, instead of undergoing canonical C−O reductive eliminations. Importantly, the use of imine‐tethered ACP's is also feasible. Therefore, the method provides a straightforward and stereoselective entry to a wide variety of highly functionalized cyclic alcohols and amines.
Year:
2022
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2022
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2022
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2022
Year:
2022
Collaborators (5)
Fernando López
Universidade de Santiago de Compostela
Moisés Gulías
Universidade de Santiago de Compostela
Maria J Macias
Professor
Instituciò Catalana de Recerca i Estudis Avancats
M. Eugenio Vazquez Sentis
Associate Professor
Universidade de Santiago de Compostela
Fernando López
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