Jose Luis Rosa

Professor

University of Barcelona

Spain

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Jose Luis Rosa is a Professor at Universitat de Barcelona, Spain. His research primarily focuses on the molecular mechanisms of diseases related to ubiquitin signaling, autophagy, and bone metabolism. Recent articles highlight his work on PI3Kα inhibition and its effects on osteochondroprogenitor specification, as well as the role of HERC proteins in various cellular responses.

Articles (13)

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2025

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2025

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2024

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2023

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2023

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2023

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2022

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2022

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2020

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2020

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2020

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2020

Collaborators (5)

Rocio Ruiz

Profesora Titular de Universidad

Universidad de Sevilla Facultad de Farmacia

SPAIN

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Ramon Bartrons

Professor

University of Barcelona

SPAIN

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Cristina Sánchez-de-Diego

University of Wisconsin-Madison

UNITED STATES

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Francesc Ventura

SPAIN

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Eva Maria Pérez Villegas

Universidad Pablo de Olavide

SPAIN

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Jose Luis Rosa

Research Interests

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Articles (13)

PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification

PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification

Autophagy dysregulation via the USP20-ULK1 axis in the HERC2-related neurodevelopmental disorder

Regulation of Ubiquitin Family Signaling in Disease

Regulation of MAPK Signaling Pathways by the Large HERC Ubiquitin Ligases

HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling

The HERC proteins and the nervous system

HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress

NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression

Regulation of the MDM2-p53 pathway by the ubiquitin ligase HERC2

The ubiquitin ligase HERC1 regulates cell migration via RAF-dependent regulation of MKK3/p38 signaling

A new homozygous HERC1 gain-of-function variant in MDFPMR syndrome leads to mTORC1 hyperactivation and reduced autophagy during cell catabolism

HERC Ubiquitin Ligases in Cancer

Collaborators (5)

Rocio Ruiz

Ramon Bartrons

Cristina Sánchez-de-Diego

Francesc Ventura

Eva Maria Pérez Villegas

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