Joseph Che-Yen Wang

Assistant Professor

Penn State College of Medicine

United States

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Joseph Che-Yen Wang is an Assistant Professor at Penn State College of Medicine, USA. His research focuses on the structural biology of viruses, particularly in understanding Hepatitis B virus and virus-like particles through methodologies such as cryo-electron microscopy and charge detection mass spectrometry. Recent articles highlight his work on virus capsid structures, genome exposure dynamics, and the development of genetically engineered nanoparticles.

Articles (15)

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2025

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2025

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2024

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2022

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2022

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2021

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2021

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2021

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2021

Collaborators (5)

Marcel Conrady

Lecturer

TH Bingen University of Applied Sciences

GERMANY

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Adam Zlotnick

Professor

Indiana University Bloomington

UNITED STATES

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Craig Meyers

UNITED STATES

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Martin Jarrold

Indiana State University

UNITED STATES

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Jodi Hadden-Perilla

Assistant Professor

University of Delaware

UNITED STATES

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Joseph Che-Yen Wang

Research Interests

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Articles (15)

Genetically Engineered, Multichromophore Virus-Like Nanoparticles with Ultranarrow Distribution of Emission Intensity

Bilayer or Not: Revisiting the Structural Nature of HBV Subviral Particles

A narrow ratio of nucleic acid to SARS-CoV-2 N-protein enables phase separation

Unveiling the Molecular Architecture of HBV Spherical Subviral Particles: Structure, Symmetry, and Lipid Dynamics

Charge Detection Mass Spectrometry Reveals Favored Structures in the Assembly of Virus-Like Particles: Polymorphism in Norovirus GI.1

Structure of the Hepatitis B virus capsid quasi-6-fold with a trapped C-terminal domain reveals capsid movements associated with domain exit

Cryo-EM structures of human hepatitis B and woodchuck hepatitis virus small spherical subviral particles

Region-Specific Hepatitis B Virus Genome Exposure from Nucleocapsid Modulated by Capsid Linker Sequence and Inhibitor: Implications for Uncoating.

Hypochlorous acid as a disinfectant for high-risk HPV: Insight into the mechanism of action.

Mutations at the Alphavirus E1'-E2 Interdimer Interface Have Host-Specific Phenotypes

Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2

Controlled Modular Multivalent Presentation of the CD40 Ligand on P22 Virus-like Particles Leads to Tunable Amplification of CD40 Signaling

Sample Preparation using a Lipid Monolayer Method for Electron Crystallographic Studies.

Core Protein-Directed Antivirals and Importin β Can Synergistically Disrupt Hepatitis B Virus Capsids.

Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry

Collaborators (5)

Marcel Conrady

Adam Zlotnick

Craig Meyers

Martin Jarrold

Jodi Hadden-Perilla

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