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Joseph M Hayes

Lecturer in Synthetic Biology

University of Central Lancashire

United Kingdom

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Research Interests

Biochemistry

40%

Pharmacology

40%

Chemical Biology

60%

Ligand Design

40%

Molecular Docking

30%

G Protein-coupled Receptor

20%

Kinase Biology

20%

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Articles16

Synthesis, In Silico and Kinetics Evaluation of N-(β-d-glucopyranosyl)-2-arylimidazole-4(5)-carboxamides and N-(β-d-glucopyranosyl)-4(5)-arylimidazole-2-carboxamides as Glycogen Phosphorylase Inhibitors

Article Link

Year:

2024

Discovery of Potent Multikinase Type-II Inhibitors Targeting CDK5 in the DFG-out Inactive State with Promising Potential against Glioblastoma

Article Link

Year:

2024

Evidence for the Quercetin Binding Site of Glycogen Phosphorylase as a Target for Liver-Isoform-Selective Inhibitors against Glioblastoma: Investigation of Flavanols Epigallocatechin Gallate and Epigallocatechin

Article Link

Year:

2024

<i>In Silico</i>-Motivated Discovery of Novel Potent Glycogen Synthase-3 Inhibitors: 1-(Alkyl/arylamino)-3H-naphtho[1,2,3-de]quinoline-2,7-dione Identified as a Scaffold for Kinase Inhibitor Development

Article Link

Year:

2023

Design and Synthesis of 3-(β-<span style="font-variant: small-caps">d</span>-Glucopyranosyl)-4-amino/4-guanidino Pyrazole Derivatives and Analysis of Their Glycogen Phosphorylase Inhibitory Potential

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Year:

2023

Design and Synthesis of 3-(beta-D-Glucopyranosyl)-4-amino/4-guanidino Pyrazole Derivatives and Analysis of Their Glycogen Phosphorylase Inhibitory Potential

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Year:

2023

In Silico-Motivated Discovery of Novel Potent Glycogen Synthase-3 Inhibitors: 1-(Alkyl/arylamino)-3H-naphtho[1,2,3-de]quinoline-2,7-dione Identified as a Scaffold for Kinase Inhibitor Development

Article Link

Year:

2023

Multidisciplinary docking, kinetics and X-ray crystallography studies of baicalein acting as a glycogen phosphorylase inhibitor and determination of its' potential against glioblastoma in cellular models

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Year:

2023

2-Acetamido-2-deoxy-d-glucono-1,5-lactone Sulfonylhydrazones: Synthesis and Evaluation as Inhibitors of Human OGA and HexB Enzymes

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Year:

2022

The druggability of the ATP binding site of glycogen phosphorylase kinase probed by coumarin analogues

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Year:

2022

2-Acetamido-2-deoxy-d-glucono-1,5-lactone Sulfonylhydrazones: Synthesis and Evaluation as Inhibitors of Human OGA and HexB Enzymes

Article Link

Year:

2022

Novel diarylamides and diarylureas with N-substitution dependent activity against medulloblastoma

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Year:

2021

Nanomolar inhibition of human OGA by 2-acetamido-2-deoxy-d-glucono-1,5-lactone semicarbazone derivatives

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Year:

2021

Structure-Based Design of Potent Selective Nanomolar Type-II Inhibitors of Glycogen Synthase Kinase-3β

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Year:

2021

Aromatic Stacking Facilitated Self-Assembly of Ultrashort Ionic Complementary Peptide Sequence: β-Sheet Nanofibers with Remarkable Gelation and Interfacial Properties

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Year:

2020

Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors

Article Link

Year:

2020

Collaborators11

Jane Elizabeth Alder

Deputy Head of School

University of Central Lancashire

UNITED KINGDOM

Mohamed Elsawy

Senior Lecturer in Pharmaceutical Sciences

De Montfort University

UNITED KINGDOM

István Timári

University of Debrecen

HUNGARY

vikesh chhabria

Lecturer in Biomedical Sciences

Cardiff University

UNITED KINGDOM

Araida Hidalgo-Bastida

Manchester Metropolitan University

UNITED KINGDOM

Philip Welsby

Associate Head PG/CPD Medical Education, Programme Lead Masters in Medicine (MMed)

Edge Hill University

UNITED KINGDOM

Caroline Topham

Lecturer in Translational Medicine

University of Salford

UNITED KINGDOM

Sándor Kun

Senior lecturer

University of Debrecen

HUNGARY

Timothy J. Snape

De Montfort University

UNITED KINGDOM

Anna-Maria G. Psarra

University of Thessaly

GREECE

László Somsák

University of Debrecen

HUNGARY

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