Joseph Pierre

Has grant

Assistant Professor

University of Wisconsin-Madison

United States

Research Interests

Explore related searches

Professors in United States Professors in Microbiology Microbiology professors in United States

Contact this professor

Get a free first email built on one of their papers, ready for you to edit and send yourself.

About

Joseph Pierre is an Assistant Professor at the University of Wisconsin–Madison. His research focuses on gut microbiota, nutritional interventions, and their effects on health, particularly in relation to obesity, cancer, and chronic diseases. Recent articles authored by Professor Pierre explore various aspects of diet and microbiome interactions, including the impact of processed pearl millet and the role of specific gut bacteria in health outcomes.

Recent Grants

Grant: Close

Improving immunotherapy through bariatric surgery and microbially-derived metabolites to reduce obesity-associated breast cancer

Open Date: 2020-08-01

Close Date: 2025-05-01

Grant: Close

Experimental studies of a novel antimicrobial peptide regulator of fungal commensalism

Open Date: 2016-01-01

Close Date: 2016-12-01

Grant: Close

Novel role and function of Paneth cell PYY in anti-fungal innate immunity

Open Date: 2015-07-01

Close Date: 2016-06-30

Articles (20)

Year:

2025

Year:

2024

Year:

2024

Year:

2024

Year:

2024

The mammalian gut secretes a family of multifunctional peptides that affect appetite, intestinal secretions, and motility whereas others regulate the microbiota. We have found that peptide YY (PYY 1-36 ), but not endocrine PYY 3-36 , acts as an antimicrobial peptide (AMP) expressed by gut epithelial paneth cells (PC). PC-PYY is packaged into secretory granules and is secreted into and retained by surface mucus, which optimizes PC-PYY activity. Although PC-PYY shows some antibacterial activity, it displays selective antifungal activity against virulent Candida albicans hyphae—but not the yeast form. PC-PYY is a cationic molecule that interacts with the anionic surfaces of fungal hyphae to cause membrane disruption and transcriptional reprogramming that selects for the yeast phenotype. Hence, PC-PYY is an antifungal AMP that contributes to the maintenance of gut fungal commensalism.

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2021

Year:

2021

Year:

2020

Year:

2020

Year:

2020

Year:

2020

Year:

2020

Year:

2020

Year:

2020

Year:

2020

Collaborators (14)

Justin Stewart

University of Amsterdam

NETHERLANDS

View details

Brooke M Bullard

Assistant Professor of Biology

University of Tennessee Health Science Center

UNITED STATES

View details

ApplyKite TwinLearns as you apply

Make your next move.

Prepare your application

Review drafts before you send them.

Joseph Pierre

Research Interests

Explore related searches

Contact this professor

About

Recent Grants

Articles (20)

Processed Pearl Millet Improves the Morphology and Gut Microbiota in Wistar Rats

FXR Agonism with Bile Acid Mimetic Reduces Pre-Clinical Triple-Negative Breast Cancer Burden

Panaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters the immune response to mitigate colitis

Fecal microbial transplants as investigative tools in cancer

Effects of a Sorghum Beverage with Lacticaseibacillus paracasei on Body Composition, Lipid Profiles, and Intestinal Health in Overweight and Obese Adults: A Randomized Single-Blind Pilot Study

Peptide YY: A Paneth cell antimicrobial peptide that maintains <i>Candida</i> gut commensalism

Altered Hepatic and Intestinal Homeostasis in a Neonatal Murine Model of Short-Term Total Parenteral Nutrition and Antibiotics

Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment

Gut Microbiota-Targeted Interventions in the Management of Chronic Kidney Disease

TRPV6 deficiency attenuates stress and corticosterone-mediated exacerbation of alcohol-induced gut barrier dysfunction and systemic inflammation

The gut mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to diet.

Chronic stress and corticosterone exacerbate alcohol-induced tissue injury in the gut-liver-brain axis.

Discovery and predictive modeling of urine microbiome, metabolite and cytokine biomarkers in hospitalized patients with community acquired pneumonia.

Altered gut microbiota in infants is associated with respiratory syncytial virus disease severity.

A stable cutaneous mycobiome exists from birth.

Microbiome, bile acids, and obesity: How microbially modified metabolites shape anti-tumor immunity.

Reply to "Letter to Editor: Takeda-G Protein Receptor-5 signaling mitigates parenteral nutrition-associated liver disease: public health impact".

Gastric Bypass Improves Obesity and Glucose Tolerance Independent of Gastric Pouch Size.

TGR5 Signaling Mitigates Parenteral Nutrition Associated Liver Disease.

Time of Feeding Alters Obesity-Associated Parameters and Gut Bacterial Communities, but Not Fungal Populations, in C57BL/6 Male Mice.

Collaborators (14)

Justin Stewart

Brooke M Bullard

Erin Stephenson

Eugene B. Chang

Heather Smallwood

Kent Willis

Liza Makowski

Brian M Peters

Joan Han

Ioulia Chatzistamou

Madeline Pye

Laura Sipe

Katherine Cook

Ajay Talati

Make your next move.