Joshua Wythe

Associate Professor

University of Virginia School of Medicine

United States

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About

Joshua Wythe is an Associate Professor at the School of Medicine, University of Virginia, USA. His research focuses on endothelial cell biology and vascular development, with recent articles examining the transcriptional and epigenetic landscapes of endothelial diversity, the implications of inflammation in brain arteriovenous malformations, and innovative murine models for studying vascular conditions. His work also explores advanced methodologies for tissue clearing and drug testing in vascular networks.

Articles (13)

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2025

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2025

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2024

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2024

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2023

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2022

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2022

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2022

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2022

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2022

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2021

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2020

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2020

Collaborators (6)

Oriol Iborra Egea

Chief Executive Officer

NIMBLE Diagnostics, S.L

SPAIN

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Yuka Morikawa

Texas Heart Institute

UNITED STATES

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Xiao Li

Assistant Professor

Baylor College of Medicine

UNITED STATES

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Chih-Wei Hsu

Assistant Professor

Baylor College of Medicine

UNITED STATES

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Cameron McAlpine

Associate Professor

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Mary E. Dickinson

Baylor College of Medicine

UNITED STATES

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Joshua Wythe

Research Interests

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Articles (13)

Mapping the transcriptional and epigenetic landscape of organotypic endothelial diversity in the developing and adult mouse

From bench to bedside: murine models of inherited and sporadic brain arteriovenous malformations

Endothelial cells adopt a pro-reparative immune responsive signature during cardiac injury

Protocol for optical, aqueous-based clearing of murine tissues using EZ Clear

The Role and Therapeutic Implications of Inflammation in the Pathogenesis of Brain Arteriovenous Malformations.

EZ Clear for simple, rapid, and robust mouse whole organ clearing

A human model of arteriovenous malformation (AVM)-on-a-chip reproduces key disease hallmarks and enables drug testing in perfused human vessel networks.

Computational insights on coronary artery function

FOXO1 represses sprouty 2 and sprouty 4 expression to promote arterial specification and vascular remodeling in the mouse yolk sac

RBFOX2 is required for establishing RNA regulatory networks essential for heart development.

Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease.

Somatic Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK but Not PI3K Signaling

Development of barium‐based low viscosity contrast agents for micro CT vascular casting: Application to 3D visualization of the adult mouse cerebrovasculature

Collaborators (6)

Oriol Iborra Egea

Yuka Morikawa

Xiao Li

Chih-Wei Hsu

Cameron McAlpine

Mary E. Dickinson

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