Jérémie Le Pen

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Assistant professor of Immunology and Infectious Diseases

Harvard University

United States

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About

Jérémie Le Pen is an Assistant Professor of Immunology and Infectious Diseases at Harvard University, USA. His research focuses on the molecular mechanisms of immune response to infectious diseases, particularly in relation to SARS-CoV-2 and its variants. Recent articles reflect his work on type I interferon production, the innate immune response, and the role of specific proteins in virus entry and pathogenesis.

Recent Grants

Grant: Close

Transgenerational epigenetic inheritance in C.elegans.

Open Date: 2010-10-01

Close Date: 2014-09-30

Articles (10)

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2025

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2025

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2024

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2024

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2024

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2023

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2022

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2022

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2021

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2020

Collaborators (22)

Volker Thiel

Professor and Chair Virology

University of Bern

SWITZERLAND

Jérémie Le Pen

Research Interests

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About

Recent Grants

Articles (10)

A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity

Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains.

SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency.

A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist.

The antiviral state of the cell: lessons from SARS-CoV-2

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia

ER-associated RNA silencing promotes ER quality control

Replication and single-cycle delivery of SARS-CoV-2 replicons

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

Collaborators (22)

Volker Thiel

Mikko Seppänen

Stuart Turvey

Andrew Leal

Eric Miska

Qian Zhang

Ahmad Yatim

Alexandre Belot

Takaki Asano

Laurent Renia

Daniel Blázquez-Gamero

Michael Wilson

Peng Zhang

Roger Colobran

Sonia Ravanelli

Katerina Slaba

Carlos Rodríguez-Gallego

Megan Cooper

Javier Fernandez-Martinez

Joseph Luna

Eleftherios Michailidis

Fabrice Jaffré

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