Jun Chen

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Richard K. Mellon Professor and Director

University of Pittsburgh

United States

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Recent Grants

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Novel strategies to improve stroke recovery in aged mice

Open Date: 2022-07-01

Close Date: 2025-06-30

Grant: Close

Activation of the RXR/PPARγ axis improves long-term outcomes after ischemic stroke in aged mice

Open Date: 2022-01-01

Close Date: 2025-12-01

Grant: Close

Novel role and mechanisms of histone deacetylases in traumatic brain injury

Open Date: 2018-07-01

Close Date: 2024-06-01

Grant: Close

Inflammation resolution, neuroprotection, and brain repair to promote stroke recovery

Open Date: 2017-08-01

Close Date: 2023-05-01

Grant: Close

Interleukin-4 as a novel therapy for traumatic brain injury

Open Date: 2016-10-01

Close Date: 2021-09-01

Articles (9)

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2024

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2022

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2021

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2020

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2020

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2020

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2020

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2020

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2020

Collaborators (1)

Sherry H.-Y. Chou

Northwestern University Feinberg School of Medicine

UNITED STATES

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Jun Chen

Research Interests

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Recent Grants

Articles (9)

Loss of microRNA-15a/16-1 function promotes neuropathological and functional recovery in experimental traumatic brain injury

STAT1 Contributes to Microglial/Macrophage Inflammation and Neurological Dysfunction in a Mouse Model of Traumatic Brain Injury

IL33 (Interleukin 33)/ST2 (Interleukin 1 Receptor-Like 1) Axis Drives Protective Microglial Responses and Promotes White Matter Integrity After Stroke

Microglial Responses to Brain Injury and Disease: Functional Diversity and New Opportunities.

IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice.

Interleukin-4 improves white matter integrity and functional recovery after murine traumatic brain injury via oligodendroglial PPARγ.

Endothelium-Targeted Deletion of microRNA-15a/16-1 Promotes Poststroke Angiogenesis and Improves Long-Term Neurological Recovery.

Transcriptomic and functional studies reveal undermined chemotactic and angiostimulatory properties of aged microglia during stroke recovery.

Transforming Growth Factor Beta-Activated Kinase 1-Dependent Microglial and Macrophage Responses Aggravate Long-Term Outcomes After Ischemic Stroke.

Collaborators (1)

Sherry H.-Y. Chou

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