Juro Sakai

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Professor

Tohoku University

Japan

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モジュールタンパク質の時空間的インタープレイによるエンハンサー活性化機構の解明研究課題

Open Date: 2022-06-01

Close Date: 2026-03-01

Grant: Close

シグナル感知エピゲノム酵素による世代を超えた環境適応機構の解明

Open Date: 2021-04-05

Close Date: 2024-03-31

Grant: Close

生活習慣病予防に働く早期ライフステージの生活環境記憶の解明

Open Date: 2020-10-01

Close Date: 2026-03-01

Grant: Close

栄養-代謝-エピゲノム軸による細胞機能調節の仕組みを解明

Open Date: 2020-07-30

Close Date: 2022-03-31

Grant: Close

代謝入力による脂肪細胞の遺伝子発現機構の解明

Open Date: 2020-04-01

Close Date: 2022-03-31

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Collaborators (16)

Kohsuke Takeda

Nagasaki University

JAPAN

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Tomohiro Suzuki

Assistant professor

Gunma University

JAPAN

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Hideki Nishitoh

University of Miyazaki

JAPAN

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Reika Kawabata-Iwakawa

Gunma University

JAPAN

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Robert Bruce Russell

Professor

Ruprecht Karls Universität Heidelberg

GERMANY

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Keisuke Maeda

Project Assistant Professor

Nagoya University

JAPAN

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Chaoran Yang

Monash University Malaysia.

AUSTRALIA

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Tetsuro Komatsu

Gunma University

JAPAN

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Christiane Zorbas

Université libre de Bruxelles

BELGIUM

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takeshi inagaki

Professor

JAPAN

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KATSUTARO MORINO

Associate Professor

Shiga University of Medical Science

JAPAN

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Yoshihiro Matsumura

Associate Professor

Tohoku Daigaku Daigakuin Igakukei Kenkyuka Igakubu

JAPAN

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Marco Candeias

Junior Associate Professor - Principal Investigator

Kyoto University

JAPAN

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Zeyang Shen

National Human Genome Research Institute

UNITED STATES

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Takashi Ito

Professor

Kyushu University

JAPAN

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Shin-ichi Inoue

University of Pennsylvania

UNITED STATES

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Juro Sakai

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Articles (20)

Acetate derived from the intestinal tract has a critical role in maintaining skeletal muscle mass and strength in mice

Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease

Article Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease

A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation

A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation

Environmental factor reversibly determines cellular identity through opposing Integrators that unify epigenetic and transcriptional pathways

Epitranscriptomics in metabolic disease

Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity

Chemogenetic activation of G12 signaling enhances adipose tissue browning

Environmental factor reversibly determines cellular identity through opposing Integrators that unify epigenetic and transcriptional pathways

Hypoxia activates <scp>SREBP2</scp> through Golgi disassembly in bone marrow‐derived monocytes for enhanced tumor growth

Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth

RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression

Epigenetic and environmental regulation of adipocyte function.

MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis.

Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors.

Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alcoholic Steatohepatitis

Ubiquitination‐dependent and ‐independent repression of target genes by SETDB1 reveal a context‐dependent role for its methyltransferase activity during adipogenesis

Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals.

ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function

Collaborators (16)

Kohsuke Takeda

Tomohiro Suzuki

Hideki Nishitoh

Reika Kawabata-Iwakawa

Robert Bruce Russell

Keisuke Maeda

Chaoran Yang

Tetsuro Komatsu

Christiane Zorbas

takeshi inagaki

KATSUTARO MORINO

Yoshihiro Matsumura

Marco Candeias

Zeyang Shen

Takashi Ito

Shin-ichi Inoue

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