Karl Gademann

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Full professor

University of Zurich

Switzerland

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About

Professor Karl Gademann is a Full Professor at Universität Zürich, Switzerland. His research primarily focuses on the synthesis and characterization of complex natural products and their derivatives, as evidenced by his recent publications in areas such as chemoproteomics, marine natural product synthesis, and biosynthetic pathways. He is actively engaged in exploring novel drug delivery systems and enhancing antibiotic stability through innovative chemical modifications.

Recent Grants

Grant: Close

A New Class of Signal Molecules in Bacteria: Data-Driven Discovery, Mechanism, and Biological Function (Signalin’Bac)

Open Date: 2019-10-01

Close Date: 2023-09-30

Grant: Close

Ion Mobility Mass Spectrometry to Unscramble Complex Biological Samples

Open Date: 2019-09-01

Close Date: 2020-08-31

Grant: Close

Mechanism-Based Design, Synthesis, Biological Evaluation, and Delivery of Next-Generation Antibiotics

Open Date: 2019-01-01

Close Date: 2022-12-31

Grant: Close

Copper availability, methanobactin production and methane oxidation in two Swiss lakes: Constraints on copper acquisition by methanotrophic bacteria

Open Date: 2016-06-01

Close Date: 2019-05-31

Grant: Close

Directing Neurite Outgrowth through Synthetic Natural Products

Open Date: 2015-10-01

Close Date: 2018-09-30

Articles (19)

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2025

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2022

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2022

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2022

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2021

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2021

Collaborators (4)

Susanne Sievers

University of Greifswald

GERMANY

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Timo Niedermeyer

Professor

Freie Universität Berlin

GERMANY

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Michel Rickhaus

SWITZERLAND

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Elisabeth Janssen

Deputy Department Head

Swiss Federal Institute of Aquatic Science and Technology

SWITZERLAND

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Karl Gademann

Research Interests

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About

Recent Grants

Articles (19)

Valdiazen Derivatives for Chemoproteomic Studies in Burkholderia cenocepacia H111

Syntheses of Structurally Complex Marine Cyclopropyl‐Diterpenoids: Peyssonnoside A and Its Aglycon

Synthesis of 2-acetylnoviosamine derivatives by hydrogenolytic cleavage of a spirocyclopropane

UV–vis absorbance spectra, molar extinction coefficients and circular dichroism spectra for the two cyanobacterial metabolites anabaenopeptin A and anabaenopeptin B

Formal Single Atom Editing of the Glycosylated Natural Product Fidaxomicin Improves Acid Stability and Retains Antibiotic Activity

Isolation of Fidaxomicin and Shunt Metabolites from Actinoplanes deccanensis

Bifunctional Sildenafil Diazeniumdiolates Acting as Phosphodiesterase 5 Inhibitors and Nitric Oxide Donors− Towards Wound Healing

Functional biosynthetic stereodivergence in a gene cluster via a dihydrosydnone N-oxide

Total Synthesis of (−)-Bipolarolide D

Biohybrid Microswimmers for Antibiotic Drug Delivery Based on a Thiol‐Sensitive Release Platform

Clinically Approved Antibiotics from 2010 to 2022

Preparation of 3‐Bromo‐1,2,4,5‐tetrazine

Cross-Coupling Reactions of 5-Bromo-1,2,3-triazine

Synthesis and Antimicrobial Evaluation of New Cephalosporin Derivatives Containing Cyclic Disulfide Moieties

Mechanistic Studies and Data Science-Guided Exploration of Bromotetrazine Cross-Coupling

Antibody Recognition of Cancer Cells via Glycan Surface Engineering

Total syntheses of strained polycyclic terpenes

Thiol- and Disulfide-Containing Vancomycin Derivatives Against Bacterial Resistance and Biofilm Formation

Biohybrid microswimmers against bacterial infections

Collaborators (4)

Susanne Sievers

Timo Niedermeyer

Michel Rickhaus

Elisabeth Janssen

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