Kazuki Heishima

G-YLC-designated assistant professor

Gifu University

Japan

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Kazuki Heishima is an assistant professor at Gifu University, Japan. His research focuses on the roles of microRNAs in cardiac function and cancer therapy, with recent articles examining the restoration effects of modified microRNA-143 on myocardial infarction and the antitumor effects of miR-143 in colorectal cancer models. He is also investigating the potential of non-rodent models for drug discovery in angiosarcoma and the molecular mechanisms involved in early bladder cancer.

Articles (16)

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2025

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2024

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2023

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2020

Collaborators (4)

Tomohiro Itoh

Mie university

JAPAN

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Masashi Nishikawa

Assistant professor

Nagoya University

JAPAN

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Nobuhiko Sugito

Project assistant professor

Gifu University

JAPAN

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Yukihiro Akao

Gifu University

JAPAN

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Kazuki Heishima

Research Interests

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Articles (16)

Restoration effect of chemically modified microRNA-143-3p on acute myocardial infarction in animal models

Plasma microRNA-143 and microRNA-145 levels are elevated in patients with left ventricular dysfunction

Targeting microRNA-145-mediated progressive phenotypes of early bladder cancer in a molecularly defined in vivo model

An Increase in Plasma MicroRNA-143 Levels in the Acute Phase Is Positively Correlated With Recovery of Cardiac Function in the Chronic Phase in Patients With Acute Myocardial Infarction

Antitumor effects of chemically modified miR-143 lipoplexes in a mouse model of pelvic colorectal cancer via myristoylated alanine-rich C kinase substrate downregulation

Hemangiosarcoma in dogs as a potential non-rodent animal model for drug discovery research of angiosarcoma in humans

PARP deficiency causes hypersensitivity to Taxol through oxidative stress induced DNA damage

Chemically modified MIR143-3p exhibited anti-cancer effects by impairing the KRAS network in colorectal cancer cells

Plant hvu-MIR168-3p enhances expression of glucose transporter 1 (SLC2A1) in human cells by silencing genes related to mitochondrial electron transport chain complex I

Rapid total synthesis of petasin and isopetasin

Understanding of cell death induced by the constituents of Taxus yunnanensis wood

Petasin potently inhibits mitochondrial complex I–based metabolism that supports tumor growth and metastasis

Melanoma brain metastases have lower T-cell content and microvessel density compared to matched extracranial metastases

Postoperative changes in plasma miR21-5p as a novel biomarker for colorectal cancer recurrence: A prospective study

Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains

Development of synthetic microRNA-214 showing enhanced cytotoxicity and RNase resistance for treatment of canine hemangiosarcoma

Collaborators (4)

Tomohiro Itoh

Masashi Nishikawa

Nobuhiko Sugito

Yukihiro Akao

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