Keith St Lawrence

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Professor

Western University

Canada

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Professor Keith St Lawrence is a faculty member at Western University in Canada. His research primarily focuses on the assessment of functional connectivity in neonates and adults utilizing advanced imaging techniques, including near-infrared spectroscopy and positron emission tomography. His recent publications explore topics such as cerebral hemodynamics, brain monitoring methodologies, and the implications of hypoxic ischemic encephalopathy in newborns.

Recent Grants

Grant: Open

Does Impaired Cerebral Metabolism Link Vascular Dysfunction to Cognitive Decline?

Open Date: 2022-03-01

Close Date: 2027-02-01

Grant: Close

Revealing the Functional and Molecular Mechanisms of Brain Disease with Better Imaging Tools

Open Date: 2021-03-01

Close Date: 2026-02-01

Grant: Close

Development of a non-invasive optical device to guide individualized neurointensive care

Open Date: 2021-03-01

Close Date: 2026-03-01

Grant: Close

Studying Dynamic Blood Flow/Metabolism Regulation in the Brain

Open Date: 2018-09-01

Close Date: 2023-08-01

Grant: Close

The Role of Perfusion MRI in Improving the Diagnosis of FTD subtypes and Longitudinal Monitoring of Disease Progression

Open Date: 2016-09-01

Close Date:

Articles (20)

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2024

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2020

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2020

Collaborators (6)

Daniel Milej

Assistant Professor

Western University

CANADA

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Kevin Shoemaker

Professor

University of Western Ontario

CANADA

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Michael Kovacs

University of Western Ontario

CANADA

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Emma Duerden

Assistant Professor

University of Western Ontario

CANADA

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Helen Christou

Chief of Newborn Medicine

Massachusetts General Hospital

UNITED STATES

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Justin Hicks

Assistant Professor

Western University

CANADA

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Keith St Lawrence

Research Interests

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About

Recent Grants

Articles (20)

Frugal and Translatable [<sup>15</sup>O]O<sub>2</sub> Production for Human Inhalation with Direct Delivery from the Cyclotron to a Hybrid PET/MR

Altered resting-state functional connectivity in newborns with hypoxic ischemic encephalopathy assessed using high-density functional near-infrared spectroscopy

Altered functional connectivity in preterm neonates with intraventricular hemorrhage assessed using functional near-infrared spectroscopy

Assessing changes in regional cerebral hemodynamics in adults with a high-density full-head coverage time-resolved near-infrared spectroscopy device

In vivo optical assessment of cerebral and skeletal muscle microvascular response to phenylephrine

Longitudinal clinicoradiological findings in pathologically confirmed chronic traumatic encephalopathy

Simultaneous estimation of a model-derived input function for quantifying cerebral glucose metabolism with [<sup>18</sup>F]FDG PET

Characterization of cerebral macro- and microvascular hemodynamics during transient hypotension

Development of a minimally invasive simultaneous estimation method for quantifying translocator protein binding with [<sup>18</sup>F]FEPPA positron emission tomography

Proceedings of the 14th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical, etc

A Noninvasive Method for Quantifying Cerebral Metabolic Rate of Oxygen by Hybrid PET/MRI: Validation in a Porcine Model

A non-invasive reference-based method for imaging the cerebral metabolic rate of oxygen by PET/MR: theory and error analysis.

Dynamic response of cerebral blood flow to insulin-induced hypoglycemia.

Direct assessment of extracerebral signal contamination on optical measurements of cerebral blood flow, oxygenation, and metabolism.

Validation protocol for current good manufacturing practices production of [15O]water for hybrid PET/MR studies.

Optical monitoring of cerebral perfusion and metabolism in adults during cardiac surgery with cardiopulmonary bypass.

Quantification of cerebral blood flow in adults by contrast-enhanced near-infrared spectroscopy: Validation against MRI

Characterizing dynamic cerebral vascular reactivity using a hybrid system combining time-resolved near-infrared and diffuse correlation spectroscopy.

Perfusion and Metabolic Neuromonitoring during Ventricular Taps in Infants with Post-Hemorrhagic Ventricular Dilatation.

Assessing Time-Resolved fNIRS for Brain-Computer Interface Applications of Mental Communication.

Collaborators (6)

Daniel Milej

Kevin Shoemaker

Michael Kovacs

Emma Duerden

Helen Christou

Justin Hicks

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