Kelvin Luk

Research Associate Professor

University of Pennsylvania

United States

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About

Kelvin Luk is a Research Associate Professor at the University of Pennsylvania. His research focuses on neurodegenerative diseases, particularly the mechanisms underlying synucleinopathies and their relationships with neuroinflammation and neurodegeneration. Recent publications include studies on α-synuclein aggregation in Parkinson's disease and the impact of environmental toxins on dopamine neurotransmission.

Articles (17)

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2025

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2020

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2020

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2020

Collaborators (17)

Zachary Freyberg

Associate Professor

University of Pittsburgh

UNITED STATES

Kelvin Luk

Research Interests

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Articles (17)

Glycine-to-aspartic acid mutation at codon 51 in Snca disrupts the synaptic localisation of α-synuclein and enhances its propensity for synucleinopathy

Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease

Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions

Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils

Developmental exposure to the Parkinson’s disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice

α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice

Combining fibril‐induced alpha‐synuclein aggregation and 6‐hydroxydopamine in a mouse model of Parkinson's disease and the effect of cerebral dopamine neurotrophic factor on the induced neurodegeneration

A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes

A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy

Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search

The variance in phosphorylated, insoluble ⍺-synuclein in humans, rats, and mice is not mainly driven by biological sex

Dopamine neurons exhibit emergent glutamatergic identity in Parkinson’s disease

Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS

Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits

Snca-GFP Knock-In Mice Reflect Patterns of Endogenous Expression and Pathological Seeding

Cell-to-Cell Transmission of Tau and α-Synuclein

Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease

Collaborators (17)

Zachary Freyberg

Aastha Singh

Jack Lipton

Scott E Counts

Nathan Kuhn

Eric Ramsson

Tilo Kunath

Katheryn Alexandra Quilico Cousins

Caryl E. Sortwell

Norihito Uemura

Masato Koike

Maiko Uemura

Thomas Steinkellner

Alison Bernstein

Joseph Patterson

Thomas Hnasko

Chester Mathis

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