Ken Mackie

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University of Washington Medical Center

United States

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Recent Grants

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Role of CB2 in Analgesic Mechanisms

Open Date: 2016-04-15

Close Date: 2021-01-31

Grant: Close

Adolescent THC, microglial activation, neuroinflammation, and their long-term consequences

Open Date: 2015-04-01

Close Date: 2017-03-31

Grant: Close

Cannabinoid Modulation of Cell Function

Open Date: 2005-10-18

Close Date: 2018-03-31

Grant: Close

Neuronal cannabinoids

Open Date: 1998-04-01

Close Date: 2016-06-30

Articles (20)

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Collaborators (10)

Jason Tchieu

Assistant Professor

Cincinnati Children's Hospital Medical Center

UNITED STATES

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Iain Greig

University of Aberdeen

UNITED KINGDOM

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Andrea G. Hohmann

UNITED STATES

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Giuseppe Gangarossa

Tenured Assistant Professor

Université Paris-Saclay

FRANCE

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Jaroslav Blahos

Institute of Molecular Genetics

CZECH REPUBLIC

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Jessica Biddinger

Vanderbilt University

UNITED STATES

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Isin Cakir

Assistant Professor of Medicine

University of Pittsburgh

UNITED STATES

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Cecilia J. Hillard

UNITED STATES

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Petr Palivec

University of Chemistry and Technology

CZECH REPUBLIC

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Feng Guo

UNITED STATES

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Ken Mackie

Research Interests

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Recent Grants

Articles (20)

Mice lacking the endocannabinoid-synthesizing enzyme NAPE-PLD exhibit sex-dependent dysregulations in responsiveness to oxycodone and a natural reward

Human brain organoids for understanding substance use disorders

Hexahydrocannabinol (HHC) and Δ9-tetrahydrocannabinol (Δ9-THC) driven activation of cannabinoid receptor 1 results in biased intracellular signaling

NAPE-PLD in the ventral tegmental area regulates reward events, feeding and energy homeostasis

Human brain organoids for understanding substance use disorders

Cannabinoid CB2 receptors in primary sensory neurons are implicated in CB2 agonist-mediated suppression of paclitaxel-induced neuropathic nociception and sexually-dimorphic sparing of morphine tolerance

Cannabinoid receptor type 1 activation causes a water diuresis by inducing an acute central diabetes insipidus in mice

CB1 Receptor Negative Allosteric Modulators as a Potential Tool to Reverse Cannabinoid Toxicity

Conditional deletion of CB2 cannabinoid receptors from peripheral sensory neurons eliminates CB2-mediated antinociceptive efficacy in a mouse model of carrageenan-induced inflammatory pain

Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages

Alternative pain management via endocannabinoids in the time of the opioid epidemic: Peripheral neuromodulation and pharmacological interventions

Engineering human spinal microphysiological systems to model opioid-induced tolerance

Brain organoid reservoir computing for artificial intelligence

Instrumentation development, improvement, simplification, and miniaturization: The multifunctional plate source for use in mass spectrometry

A Critical Evaluation of Terpenoid Signaling at Cannabinoid CB1 Receptors in a Neuronal Model

A peripheral CB2 cannabinoid receptor mechanism suppresses chemotherapy-induced peripheral neuropathy: evidence from a CB2 reporter mouse

SGIP1 modulates kinetics and interactions of the cannabinoid receptor 1 and G protein‐coupled receptor kinase 3 signalosome

Human Spinal Organoid-on-a-Chip to Model Nociceptive Circuitry for Pain Therapeutics Discovery

Endogenous cannabinoids are required for MC4R-mediated control of energy homeostasis

SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB1 receptors

Collaborators (10)

Jason Tchieu

Iain Greig

Andrea G. Hohmann

Giuseppe Gangarossa

Jaroslav Blahos

Jessica Biddinger

Isin Cakir

Cecilia J. Hillard

Petr Palivec

Feng Guo

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