Kenjiro Shirane

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Lecturer

Osaka University

Japan

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Recent Grants

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The role of histone methylation in guiding de novo DNA methylation in the male germline

Open Date: 2019-10-01

Close Date: 2024-09-30

Grant: Close

Defining the Roles of Overgrowth Syndrome Genes in Shaping Developmental Gene Networks in Early Embryos

Open Date: 2019-04-01

Close Date: 2020-09-30

Articles (10)

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2024

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2023

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2023

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2022

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2022

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2022

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2021

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2021

Year:

2021

Year:

2020

Collaborators (8)

Matthew Lorincz

Professor

The University of British Columbia

CANADA

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Hidehiro Toh

National Institute of Genetics

JAPAN

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Hiroyuki Sasaki

Kyushu University

JAPAN

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Wan Kin Au Yeung

Research assistant professor

Kyushu University

JAPAN

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Katsuhiko Hayashi

Osaka University

JAPAN

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Haruhiko Koseki

Chiba University

JAPAN

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Masafumi Hayashi

Osaka University

JAPAN

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Hisato Kobayashi

Associate Professor

Nara Medical University

JAPAN

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Kenjiro Shirane

Research Interests

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Recent Grants

Articles (10)

Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells

ADAD2 functions in spermiogenesis and piRNA biogenesis in mice

The DNMT3A ADD domain is required for efficient de novo DNA methylation and maternal imprinting in mouse oocytes.

The dynamic chromatin landscape and mechanisms of DNA methylation during mouse germ cell development.

Dual role of Ovol2 on the germ cell lineage segregation during gastrulation in mouse embryogenesis.

Epigenetic Mechanisms Governing Female and Male Germline Development in Mammals

Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing

Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations.

The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes

NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing

Collaborators (8)

Matthew Lorincz

Hidehiro Toh

Hiroyuki Sasaki

Wan Kin Au Yeung

Katsuhiko Hayashi

Haruhiko Koseki

Masafumi Hayashi

Hisato Kobayashi

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