Klaus Okkenhaug

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Professor of Immunology

University of Cambridge

United Kingdom

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Novel mechanisms of regulatory T cell mediated suppression: a fundamental role for VPS34

Open Date: 2020-02-01

Close Date: 2023-01-31

Articles (11)

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2021

Collaborators (10)

Lucas Wahl

Brandeis University

UNITED STATES

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Joseph J. Sacco

Clinical Senior Lecturer

University of Liverpool

UNITED KINGDOM

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Ferhat Ay

Associate Professor

UNITED STATES

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Dávid S. Győri

assistant lecturer

Semmelweis University

HUNGARY

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Martijn Schuijs

Ghent University

BELGIUM

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Simon Eschweiler

Assistant Professor

The University of Texas MD Anderson Cancer Center

UNITED STATES

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Simon Pitchford

King’s College London

UNITED KINGDOM

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Simon Cleary

University of California, San Francisco

UNITED STATES

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Aleksandra Badura

Associate Professor

Erasmus MC

NETHERLANDS

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Andrew Schache

Professor of Head & Neck Surgery

University of Liverpool

UNITED KINGDOM

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Klaus Okkenhaug

Research Interests

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Recent Grants

Articles (11)

PI3K Inhibitors in Hematology: When One Door Closes…

BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis.

A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells.

Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs.

PI3K inhibitors are finally coming of age

Author Correction: PI3K inhibitors are finally coming of age

Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model.

PI3K in T Cell Adhesion and Trafficking.

The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection.

How to resist PI3Kδ inhibition: activate MAPK!

CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function.

Collaborators (10)

Lucas Wahl

Joseph J. Sacco

Ferhat Ay

Dávid S. Győri

Martijn Schuijs

Simon Eschweiler

Simon Pitchford

Simon Cleary

Aleksandra Badura

Andrew Schache

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