Konstantin MJ Sparrer

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Ulm University

Germany

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Recent Grants

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Intracellular trafficking in innate immunity

Open Date: 2022-01-01

Close Date:

Grant: Close

New insights into the interplay between HIV and the autophagy machinery

Open Date: 2021-07-01

Close Date: 2026-06-30

Grant: Close

The innate immune antagonism of SARS-CoV-2 ORF3a, ORF6 and ORF7a

Open Date: 2021-01-01

Close Date: 2022-12-31

Grant: Close

IMMUNOMOD

Open Date: 2020-08-01

Close Date: 2025-07-01

Grant: Close

A08* Untersuchung der Regulierung von Autophagie durch körpereigene Peptide und deren Optimierung für Infektions- und Krebstherapie

Open Date: 2020-01-01

Close Date: 2024-01-01

Articles (27)

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Collaborators (16)

Jan Münch

GERMANY

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Eva Herker

Professor

Philipps-Universität Marburg

GERMANY

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Sally Ann Lynch

IRELAND

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Caterina Prelli Bozzo

Yale University

UNITED STATES

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Janis A Müller

Philipps-Universität Marburg

GERMANY

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Susanne Klute

Universität Ulm

GERMANY

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Emily Voigt

Associate Professor

Oregon Health & Science University

UNITED STATES

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Jung-Hyun Lee

Assistant Professor

Seoul National University

SOUTH KOREA

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GuanQun Liu

Assistant Professor

McGill University

CANADA

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Jens Michaelis

Universität Ulm

GERMANY

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Rüdiger Martin Groß

University Hospital Ulm

GERMANY

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Elke Pogge von Strandmann

GERMANY

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Madhuri Sonal Salker

Eberhard Karls Universität Tübingen

GERMANY

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Frank Kirchhoff

Ulm University Medical Center

GERMANY

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David Gordon

Assistant Professor

Emory University

UNITED STATES

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Oya Cingöz

University of Glasgow

UNITED KINGDOM

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Konstantin MJ Sparrer

Research Interests

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Recent Grants

Articles (27)

Inhibition of placental trophoblast fusion by guanylate-binding protein 5

Inborn errors of canonical autophagy in neurodegenerative diseases

Host ZAP activity correlates with the levels of CpG suppression in primate lentiviruses

α-Synuclein fibrils enhance HIV-1 infection of human T cells, macrophages and microglia

Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens.

Replication competent HIV-guided CRISPR screen identifies antiviral factors including targets of the accessory protein Nef

CSNK2 suppresses autophagy by activating FLN-NHL-containing TRIM proteins

Friends and Foes: The Ambivalent Role of Autophagy in HIV-1 Infection

A naturally occurring 22-amino acid fragment of human hemoglobin A inhibits autophagy and HIV-1

Differences and similarities between innate immune evasion strategies of human coronaviruses

Interferon antagonists encoded by SARS-CoV-2 at a glance

SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor

Cap snatch prevention: a novel approach to tackle influenza viruses

ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling

Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques.

Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication

Determinants of species-specific utilization of ACE2 by human and animal coronaviruses

Impact of mutations defining SARS-CoV-2 Omicron subvariants BA.2.12.1 and BA.4/5 on Spike function and neutralization.

Regulation of STING activity in DNA sensing by ISG15 modification.

Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIV<sub>mac239</sub> in rhesus macaques.

Actin cytoskeleton remodeling primes RIG-I-like receptor activation.

Strong attenuation of SARS-CoV-2 Omicron BA.1 and increased replication of the BA.5 subvariant in human cardiomyocytes

Near-Native Visualization of SARS-CoV-2 Induced Membrane Remodeling and Virion Morphogenesis

Unexpected little helpers: microbiota stimulate systemic antiviral defenses

Actin cytoskeleton remodeling primes RIG-I-like receptor activation

Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2

Omicron: What Makes the Latest SARS-CoV-2 Variant of Concern So Concerning?

Collaborators (16)

Jan Münch

Eva Herker

Sally Ann Lynch

Caterina Prelli Bozzo

Janis A Müller

Susanne Klute

Emily Voigt

Jung-Hyun Lee

GuanQun Liu

Jens Michaelis

Rüdiger Martin Groß

Elke Pogge von Strandmann

Madhuri Sonal Salker

Frank Kirchhoff

David Gordon

Oya Cingöz

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