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Kristiina M. Huttunen

Associate Professor (Tenure Track)

University of Eastern Finland

Finland

Research Interests

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Professors in Finland Professors in Pharmaceutical Chemistry Pharmaceutical Chemistry professors in Finland

About

Kristiina M. Huttunen is an Assistant Professor at the University of Eastern Finland. Her research areas include drug delivery systems, cancer therapeutics, and the biological evaluation of boron-based agents for neutron capture therapy. Recent publications reflect her focus on the chemical disruption of thyroid hormone signaling, cellular uptake mechanisms in cancer cells, and optimizing prodrug structures for enhanced therapeutic effects.

Articles (19)

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Collaborators (15)

Paavo Honkakoski

Professor

University of Eastern Finland

FINLAND

Kristiina M. Huttunen

Research Interests

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Articles (19)

Molecular dynamics insights into structural and hydration dynamics of LAT1 bound to ligands and JPH203-induced inward-open arrest

Biological evaluation of a glucose-based boron carrier as a potential agent for boron neutron capture therapy

Enhanced Polarity of Sulfonamide Metformin Derivatives Increases Cellular Uptake and Apoptosis-Inducing Effects in Human Breast Cancer Cells

Chemical disruption of placental thyroid hormone signalling: a systematic review that highlights sex-specific effects

Optimizing the structure of repurposed metformin can improve anti-cholinesterase and anti-amyloidogenic effects

Transporter Protein Expression of Corneal Epithelium in Rabbit and Porcine: Evaluation of Models for Ocular Drug Transport Study

Asymmetric Synthesis and Biological Evaluation of Both Enantiomers of 5- and 6-Boronotryptophan as Potential Boron Delivery Agents for Boron Neutron Capture Therapy

Improving drug delivery to the brain: the prodrug approach

Amino acid derivative of probenecid potentiates apoptosis-inducing effects of vinblastine by increasing oxidative stress in a cancer cell-specific manner

Sodium-Dependent Neutral Amino Acid Transporter 2 Can Serve as a Tertiary Carrier for l-Type Amino Acid Transporter 1-Utilizing Prodrugs

Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates

Comparative Modelling of Organic Anion Transporting Polypeptides: Structural Insights and Comparison of Binding Modes

Structural Comparison of Sulfonamide-Based Derivatives That Can Improve Anti-Coagulation Properties of Metformin

Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity

L-type Amino Acid Transporter 1 Utilizing Ferulic Acid Derivatives Show Increased Drug Delivery in the Mouse Pancreas Along with Decreased Lipid Peroxidation and Prostaglandin Production

Increased/Targeted Brain (Pro)Drug Delivery via Utilization of Solute Carriers (SLCs)

Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands

Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2

Collaborators (15)

Paavo Honkakoski

Tatsiana Auchynnikava

Anu Airaksinen

Joanna Sikora

Anne Roivainen

Tetsuya Terasaki

Francesca BARTOCCINI

Heidi Kidron

Jaana Rysä

Thales Kronenberger

Mirkka Sarparanta

Tuomo Laitinen

Surachet Imlimthan

Antti Poso

Jarkko Rautio

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