Krzysztof Brzózka

Chief Scientific Officer

Relay Therapeutics Inc

Poland

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Dr. Krzysztof Brzózka is the Chief Scientific Officer at Ryvu Therapeutics in Poland. His research focuses on pharmacokinetics, drug interactions, and novel therapeutic approaches in oncology, as evidenced by his recent work on drug uptake mechanisms and inhibitors targeting oncogenic pathways. With expertise in methodologies such as equilibrium dialysis and in vitro-in vivo extrapolation, he continues to contribute significantly to the understanding of drug metabolism and therapeutic efficacy in blood cancers.

Articles (10)

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2025

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2024

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2024

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2024

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2024

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2024

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2021

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2021

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2020

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2020

Collaborators (11)

Agnieszka Graczyk-Jarzynka

Medical University of Warsaw

POLAND

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Patryk Gorniak

Instytut Hematologii i Transfuzjologii

POLAND

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Michal Pawlak

Head, associate professor

Instytut Hematologii i Transfuzjologii

POLAND

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Emilia Białopiotrowicz-Data

Institute of Hematology and Transfusion Medicine

POLAND

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Przemysław Juszczyński

Professor

Institute of Hematology and Transfusion Medicine

POLAND

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Anna Polak

assistant professor

Institute of Hematology and Transfusion Medicine

POLAND

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Malgorzata Statkiewicz

Maria Sklodowska-Curie National Research Institute of Oncology

POLAND

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Dawid Gogola

Jagiellonian University

POLAND

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Mariusz Milik

Head of Computational Drug Discovery

POLAND

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Joanna Barankiewicz

Instytut Hematologii i Transfuzjologii

POLAND

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Maria Walczak

Jagiellonian University Medical College

POLAND

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Krzysztof Brzózka

Research Interests

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Articles (10)

Implementation of a novel method for the determination of plasma protein binding of highly bound compounds using the equilibrium dialysis method coupled with extraction to the organic phase and its comparison to known methods.

Physiologically based pharmacokinetic modeling of CYP2C8 substrate rosiglitazone and its metabolite to predict metabolic drug-drug interaction

The Dual PIM/FLT3 Inhibitor MEN1703 Combines Synergistically With Gilteritinib in FLT3-ITD-Mutant Acute Myeloid Leukaemia.

Uridine 5'-Diphospho-glucuronosyltransferase 1A3 (UGT1A3) Prediction of Hepatic Clearance of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Substrate Telmisartan by Glucuronidation Using In Vitro-In Vivo Extrapolation (IVIVE).

MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma.

Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran.

Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies.

Release of adenosine-induced immunosuppression: Comprehensive characterization of dual A<sub>2A</sub>/A<sub>2B</sub> receptor antagonist.

Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock.

Discovery of a series of ester-substituted NLRP3 inflammasome inhibitors.

Collaborators (11)

Agnieszka Graczyk-Jarzynka

Patryk Gorniak

Michal Pawlak

Emilia Białopiotrowicz-Data

Przemysław Juszczyński

Anna Polak

Malgorzata Statkiewicz

Dawid Gogola

Mariusz Milik

Joanna Barankiewicz

Maria Walczak

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