Kushol Gupta

Research Assistant Professor

University of Pennsylvania

United States

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About

Kushol Gupta is a Research Assistant Professor at the University of Pennsylvania, USA. His research focuses on structural biology and the molecular mechanisms of proteins related to DNA repair, HIV integrase, and CRISPR systems. Recent articles include investigations into the Shu complex's role in preventing mutations and the structural dynamics of allosteric inhibitors of HIV integrase.

Articles (12)

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2025

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2024

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2023

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2022

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2022

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2021

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2021

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2021

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2020

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2020

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UNITED STATES

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Kushol Gupta

Research Interests

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Articles (12)

The Shu complex interacts with the replicative helicase to prevent mutations and aberrant recombination

The LexA–RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation

Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 Å resolution: Routes to inhibitor optimization

Recognition of the TDP-43 nuclear localization signal by importin α1/β.

Structural basis of cyclic oligoadenylate binding to the transcription factor Csa3 outlines cross talk between type III and type I CRISPR systems

Assembly of higher-order SMN oligomers is essential for metazoan viability and requires an exposed structural motif present in the YG zipper dimer.

Structures of full-length VanR from Streptomyces coelicolor in both the inactive and activated states.

Allosteric HIV Integrase Inhibitors Promote Formation of Inactive Branched Polymers via Homomeric Carboxy-Terminal Domain Interactions

Manipulation of a cation-π sandwich reveals conformational flexibility in phenylalanine hydroxylase.

Influence of the amino-terminal sequence on the structure and function of HIV integrase.

Hiding the Elephant in the Room with Experimental Neutrons.

Membrane Proteins Have Distinct Fast Internal Motion and Residual Conformational Entropy.

Collaborators (5)

A. Gregory Matera

Karen Fleming

Mona Batish

Eileen Jaffe

Gino Cingolani

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