Kwan Cheng

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Williams Endowed Professor of Interdisciplinary Physics

Trinity University

United States

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About

Dr. Kwan Cheng serves as the Williams Endowed Professor of Interdisciplinary Physics at Trinity University in the United States. His research primarily focuses on the molecular dynamics of amyloid oligomers and their interactions with lipid domains, with implications for Alzheimer's and diabetic diseases. Recent publications include investigations into tau fibril interactions and the design of novel ligand analogs for potential therapeutic applications.

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“Understanding Molecular Mechanisms of Amyloid Diseases from Multiscale Simulations of Early Aggregation of Disordered Protein on Lipid Nanodomains”

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Articles (13)

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2024

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2023

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2023

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2023

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2022

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2022

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2020

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2020

Collaborators (1)

Vincent Blay

UNITED STATES

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Kwan Cheng

Research Interests

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About

Recent Grants

Articles (13)

Exploring Tau Fibril-Disaggregating and Antioxidating Molecules Binding to Membrane-Bound Amyloid Oligomers Using Machine Learning-Enhanced Docking and Molecular Dynamics

Multiscale Modeling of Macromolecular Interactions between Tau-Amylin Oligomers and Asymmetric Lipid Nanodomains That Link Alzheimer’s and Diabetic Diseases

Molecular Mechanisms of Protein–Lipid Interactions and Protein Folding of Heterogeneous Amylin and Tau Oligomers on Lipid Nanodomains That Link to Alzheimer’s

Exploring the Role of Anionic Lipid Nanodomains in the Membrane Disruption and Protein Folding of Human Islet Amyloid Polypeptide Oligomers on Lipid Membrane Surfaces Using Multiscale Molecular Dynamics Simulations

Exploring the Role of Anionic Lipid Nanodomains in the Membrane Disruption and Protein Folding of Human Islet Amyloid Polypeptide Oligomers on Lipid Membrane Surfaces Using Multiscale Molecular Dynamics Simulations

Lipid domain boundary triggers membrane damage and protein folding of human islet amyloid polypeptide in the early pathogenesis of amyloid diseases

Lipid domain boundary triggers membrane damage and protein folding of human islet amyloid polypeptide in the early pathogenesis of amyloid diseases

Design and Synthesis of New Acyl Urea Analogs as Potential σ1R Ligands

Design and Synthesis of New Acyl Urea Analogs as Potential σ1R Ligands

Exploring Membrane Binding Targets of Disordered Human Tau Aggregates on Lipid Rafts Using Multiscale Molecular Dynamics Simulations

Exploring the binding kinetics and behaviors of self-aggregated beta-amyloid oligomers to phase-separated lipid rafts with or without ganglioside-clusters

Data showing the lipid conformations and membrane binding behaviors of beta-amyloid fibrils in phase-separated cholesterol-enriched lipid domains with and without glycolipid and oxidized cholesterol from coarse-grained molecular dynamics simulations

Coarse-grained MD simulations reveal beta-amyloid fibrils of various sizes bind to interfacial liquid-ordered and liquid-disordered regions in phase separated lipid rafts with diverse membrane-bound conformational states.

Collaborators (1)

Vincent Blay

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