Laszlo Tora

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France

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Recent Grants

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Structure and function of human ATAC HAT complex (acronym ATAC)

Open Date: 2022-10-01

Close Date: 2024-09-01

Grant: Close

Mechanisms of chromatin regulation of transcription

Open Date: 2022-02-01

Close Date: 2026-08-01

Grant: Close

Characterization of a new transcription initiation machinery functioning during mammalian oogenesis

Open Date: 2022-01-01

Close Date: 2024-12-01

Grant: Close

Epigenetic Complex Assembly in Space and Time (EpiCAST)

Open Date: 2020-01-01

Close Date: 2022-12-01

Grant: Close

DNA origami tools to engineer chromatin structure and function in live cells

Open Date: 2019-09-01

Close Date: 2023-08-01

Articles (16)

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2025

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2021

Collaborators (11)

Stephen Smerdon

University of Birmingham

UNITED KINGDOM

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Marc Timmers

Professor of Medical Epigenetics

Deutsches Krebsforschungszentrum

GERMANY

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Didier Devys

Associate Professor

University of Strasbourg

FRANCE

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Andrea Bernardini

Università di Milano

ITALY

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Chiara Folland

University of Western Australia

AUSTRALIA

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Gaurav Arya

Duke University

UNITED STATES

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Amélie Rodrigue

Research Professional

Centre de recherche du CHU de Québec-Université Laval

CANADA

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Imre Berger

Professor (Chair) and Director

University of Bristol

UNITED KINGDOM

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Anthony Couturier

Professionnel scientifique

CANADA

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Cristina Pina

Senior Lecturer (Associate Professor) in Biomedical Sciences

Brunel University London

UNITED KINGDOM

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Jeffrey Ranish

Professor

Institute for Systems Biology

UNITED STATES

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Laszlo Tora

Research Interests

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Contact this professor

Recent Grants

Articles (16)

Gene-specific transcript buffering revealed by perturbation of coactivator complexes

ATAC and SAGA histone acetyltransferase modules facilitate transcription factor binding to nucleosomes independent of their acetylation activity

<i>De novo</i> variants in <i>ATXN7L3</i> lead to developmental delay, hypotonia and distinctive facial features

Piggybacking functionalized DNA nanostructures into live-cell nuclei

Co-translational Assembly Pathways of Nuclear Multiprotein Complexes Involved in the Regulation of Gene Transcription

RNA polymerase II transcription initiation in holo-TFIID-depleted mouse embryonic stem cells

Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters

ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct.

Hierarchical TAF1-dependent co-translational assembly of the basal transcription factor TFIID

KAT2-mediated acetylation switches the mode of PALB2 chromatin association to safeguard genome integrity

SUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells

SAGA-Dependent Histone H2Bub1 Deubiquitination Is Essential for Cellular Ubiquitin Balance during Embryonic Development

KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia.

TAF8 regions important for TFIID lobe B assembly or for TAF2 interactions are required for embryonic stem cell survival

What defines the maternal transcriptome?

Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription

Collaborators (11)

Stephen Smerdon

Marc Timmers

Didier Devys

Andrea Bernardini

Chiara Folland

Gaurav Arya

Amélie Rodrigue

Imre Berger

Anthony Couturier

Cristina Pina

Jeffrey Ranish

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