Lawence Wackett

Distinguished McKnight University Professor

University of Minnesota System

United States

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Lawence Wackett is a Distinguished McKnight University Professor at the University of Minnesota System, USA. His research focuses on the biodegradation of per- and polyfluoroalkyl substances (PFAS), enzyme catalysis involving C–F bond cleavage, and innovative strategies for organofluorine degradation. Recent publications include studies on defluorination mechanisms, enzymatic activities related to fluorinated compounds, and the thermodynamic constraints of PFAS biodegradation.

Articles (20)

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2025

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2021

Collaborators (3)

Alptekin Aksan

University of Minnesota

UNITED STATES

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James Christenson

Associate Professor

Bielefeld University

UNITED STATES

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Yujie Men

Assistant Professor

University of California, Riverside

UNITED STATES

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Lawence Wackett

Research Interests

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About

Articles (20)

Continuous Spectrophotometric Assay for Defluorinase and Dechlorinase Activities With α‐Halocarboxylic Acids

Matrix-independent screening of defluorination in vitro and in vivo

PFAS Biodegradation and the Constraints of Thermodynamics

Confronting PFAS persistence: enzymes catalyzing C–F bond cleavage

Dual feedback inhibition of ATP-dependent caffeate activation economizes ATP in caffeate-dependent electron bifurcation

A prescription for engineering PFAS biodegradation

Phenotypic Plasticity During Organofluorine Degradation Revealed by Adaptive Evolution

Electron bifurcation and fluoride efflux systems implicated in defluorination of perfluorinated unsaturated carboxylic acids by Acetobacterium spp

The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis

Evolutionary obstacles and not C–F bond strength make PFAS persistent

A microbial evolutionary approach for a sustainable future

Toward a molecular understanding of fluoride stress in a model Pseudomonas strain

Core‐shell encapsulation formulations to stabilize desiccated Bradyrhizobium against high environmental temperature and humidity

Strategies for the Biodegradation of Polyfluorinated Compounds

Pseudomonas: versatile biocatalysts for PFAS

Microwell Fluoride Screen for Chemical, Enzymatic, and Cellular Reactions Reveals Latent Microbial Defluorination Capacity for −CF 3 Groups

Nothing lasts forever: understanding microbial biodegradation of polyfluorinated compounds and perfluorinated alkyl substances

The future of Microbial Biotechnology

Unexpected Mechanism of Biodegradation and Defluorination of 2,2-Difluoro-1,3-Benzodioxole by Pseudomonas putida F1

Why Is the Biodegradation of Polyfluorinated Compounds So Rare?

Collaborators (3)

Alptekin Aksan

James Christenson

Yujie Men

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