Lee Rubin

PI/Professor

Harvard University

United States

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Lee Rubin is a Professor at Harvard University in the United States. His research areas include neurogenesis, Parkinson's disease, and cellular models of neurological disorders, with recent publications focusing on alpha-synuclein pathology, DNA breaks in sensory neurons, and the regulation of hippocampal neurogenesis. He employs innovative techniques such as human brain-chips and multiplexed fluorescence imaging to investigate the mechanisms underlying neurodegenerative diseases and neural development.

Articles (10)

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2021

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2021

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2021

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2021

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2021

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2021

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2020

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2020

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2020

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2020

Collaborators (8)

IOSIF PEDIADITAKIS

Co-founder & Vice President, Head of Biology

Phragma Theraperutics

UNITED STATES

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Lorna Ewart

Chief Scientific Officer

Emulate (United States)

UNITED STATES

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Jeffrey Macklis

Harvard University

UNITED STATES

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Alison ONeil

Wesleyan University

UNITED STATES

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Elias Manolakos

Northeastern University

UNITED STATES

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CAMERON SADEGH

Assistant Professor

UC Davis Health System

UNITED STATES

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Shunsuke Katsuki

Kyushu University

JAPAN

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Sean Buchanan

Harvard University

UNITED STATES

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Lee Rubin

Research Interests

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Articles (10)

Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical subcerebral/corticospinal neuron identity from mouse embryonic stem cells

Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons

GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis

Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging

Accelerating diagnosis of Parkinson’s disease through risk prediction

Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.

Pro-myogenic small molecules revealed by a chemical screen on primary muscle stem cells

Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy

Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons

Collaborators (8)

IOSIF PEDIADITAKIS

Lorna Ewart

Jeffrey Macklis

Alison ONeil

Elias Manolakos

CAMERON SADEGH

Shunsuke Katsuki

Sean Buchanan

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