Leila Janani

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Deputy Head of Trial Methdology

Imperial College London

United Kingdom

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About

Leila Janani is the Deputy Head of Trial Methodology at Imperial College London, UK. Her research primarily focuses on vaccine trial design, metabolic risk factors of non-communicable diseases, and cardiovascular disease mortality prediction. She has authored several recent articles examining topics such as the efficacy of COVID-19 vaccines, treatments for severe pediatric asthma, and the legacy benefits of blood pressure treatment.

Recent Grants

Grant: Open

FLuid strategies and Inflammatory Phenotypes in the SepTIC trial (FLIP-SepTIC)

Open Date: 2023-10-01

Close Date: 2027-01-01

Grant: Open

ACORN: A multi-site randomised COntrolled trial to evaluate the impact of a group tReatment for aNtenatal anxiety

Open Date: 2023-09-01

Close Date: 2027-08-01

Grant: Close

Breathing Assistance in CHildren with bronchiolitis (BACHb): a group-sequential two-stratum multicentre open-label randomised clinical trial of respiratory support in infants with acute bronchiolitis

Open Date: 2023-04-01

Close Date: 2026-09-01

Grant: Close

Optimisation Of lipid lowering therapies using a Decision support system In patients with Acute Coronary syndrome (ZODIAC).

Open Date: 2022-01-01

Close Date: 2024-06-01

Grant: Close

A randomised, phase II UK multi-centre study to determine reactogenicity and immunogenicity of booster vaccination against ancestral and novel variants of SARS-CoV-2 (COVBOOST)

Open Date: 2021-06-01

Close Date: 2023-07-01

Articles (19)

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Collaborators (8)

Saul Faust

University of Southampton

UNITED KINGDOM

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Christopher Green

University of Birmingham

UNITED KINGDOM

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Emma Thomson

University of Glasgow

UNITED KINGDOM

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Ajay Gupta

Senior Clinical Lecturer

Queen Mary University of London

UNITED KINGDOM

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Clare Murray

professor

The University of Manchester

UNITED KINGDOM

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Jonathan Macdonald

University of Glasgow

UNITED KINGDOM

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David Antcliffe

Clinical Senior Lecturer and Honorary Consultant in Critical Care

Imperial College London

UNITED KINGDOM

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Victoria R Cornelius

UNITED KINGDOM

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Leila Janani

Research Interests

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Recent Grants

Articles (19)

Past, present, and future of Phase 3 vaccine trial design: rethinking statistics for the 21st century.

Legacy benefits of blood pressure treatment on cardiovascular events are primarily mediated by improved blood pressure variability: the ASCOT trial

Treating severe paediatric asthma with mepolizumab or omalizumab: a protocol for the TREAT randomised non-inferiority trial

Omega-3 fatty acids for intermittent claudication.

The effect of results-based motivating system on metabolic risk factors of non-communicable diseases: A field trial study.

Mortality and re-fracture rates in low trauma hip fracture.

Optimizing cardiovascular disease mortality prediction: a super learner approach in the tehran lipid and glucose study.

Efficacy and safety of basal insulins in people with type 2 diabetes mellitus: a systematic review and network meta-analysis of randomized clinical trials.

Corrigendum to "Persistence of immunogenicity after seven COVID-19 vaccines given as third dose boosters following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK: Three month analyses of the COV-BOOST trial" [J Infect 84(6) (2022) 795-813, 5511].

Persistence of immune responses after heterologous and homologous third COVID-19 vaccine dose schedules in the UK: eight-month analyses of the COV-BOOST trial

Motivating non-physician health workers to reduce the behavioral risk factors of non-communicable diseases in the community: a field trial study

The relationship between diet quality indices and odds of breast cancer in women: a case–control study

Monitoring the COVID-19 Vaccine Acceptance Trend and its Determinants Among Iranian Adults.

A Novel Role for Cytochrome P450 Epoxygenase Metabolites in Septic Shock.

Persistence of immunogenicity after seven COVID-19 vaccines given as third dose boosters following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK: Three month analyses of the COV-BOOST trial.

Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial

Effects of supplementation of vitamins D, C and E on Idiopathic Pulmonary Fibrosis (IPF): A clinical trial.

Effectiveness of pay for performance to non-physician health care providers: A systematic review.

Analysis of hand-forearm anthropometric components in assessing handgrip and pinch strengths of school-aged children and adolescents: a partial least squares (PLS) approach

Collaborators (8)

Saul Faust

Christopher Green

Emma Thomson

Ajay Gupta

Clare Murray

Jonathan Macdonald

David Antcliffe

Victoria R Cornelius

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