Lena Nguyen

Assistant Professor

University of Texas at Dallas

United States

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Dr. Lena Nguyen is an Assistant Professor at The University of Texas at Dallas, USA. Her research focuses on molecular mechanisms underlying cortical neuron development and function, particularly involving the mTOR signaling pathway. She has published several notable articles addressing gene expression in mouse models related to epilepsy and cortical dysplasia, contributing valuable insights into neuronal dysfunction and developmental changes.

Articles (11)

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2025

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2025

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2024

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2024

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2022

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2022

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2022

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2021

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2021

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2020

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2020

Collaborators (2)

Matthew Binder

Assistant Professor

Trinity University

UNITED STATES

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Angélique Bordey

Yale University School of Medicine

UNITED STATES

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Lena Nguyen

Research Interests

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Articles (11)

Evaluation of suitable reference genes for gene expression studies in the developing mouse cortex using RT-qPCR

GAPDH, β-actin, and β-tubulin display age-dependent protein expression changes in the mouse cortex during development.

The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function

The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function

Loss of PTEN phosphorylation via single point mutation alters cortical connectivity and behaviour

Current Review in Basic Science: Animal Models of Focal Cortical Dysplasia and Epilepsy

Inhibition of MEK-ERK signaling reduces seizures in two mouse models of tuberous sclerosis complex.

Expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy.

Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies

Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice

Filamin A inhibition reduces seizure activity in a mouse model of focal cortical malformations

Collaborators (2)

Matthew Binder

Angélique Bordey

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