Lenise J Kim
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Research Assistant Professor
United StatesResearch Interests
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About
Dr. Lenise J Kim is a Research Assistant Professor at George Washington University in the United States. Her research primarily focuses on the effects of diet-induced obesity on sleep and breathing, with recent publications examining the relationship between sleep fragmentation and metabolic dysfunction. She has also explored the impact of age, sex, and body mass index on respiratory function and has investigated therapeutic approaches for sleep-disordered breathing in obese populations.
Recent Grants
Grant: Close
Leptin signaling in the carotid body: mechanisms and consequences
Open Date: 2021-04-01
Close Date: 2025-03-01
Grant: Close
Role of leptin-TRPM7 signaling in carotid bodies in the pathogenesis of sleep-disordered breathing in obesity
Open Date: 2021-04-01
Close Date: 2023-01-31
Grant: Close
Treatment of sleep apnea by targeting leptin signaling
Open Date: 2020-04-01
Close Date: 2024-03-01
Articles (10)
Year:
2023
Year:
2023
Year:
2023
Year:
2023
Year:
2023
Our diet-induced obesity (DIO) model reproduces sleep features of human obesity, including sleep fragmentation, increased apnea frequency, and larger breathing variability. DIO induces sleep fragmentation independently of apnea severity. Sleep fragmentation in DIO mice is mainly attributed to non-respiratory arousals. Increased breathing variability during sleep did not account for the higher arousal frequency in DIO. Our results provide a rationale to examine sleep in patients with obesity even when they are adequately treated for sleep-disordered breathing.
Year:
2022
Year:
2022
Year:
2022
Year:
2022
Year:
2021
Collaborators (4)
Luu V. Pham
Johns Hopkins University School of Medicine
Alban Latremoliere
Assistant Professor
Johns Hopkins University
Daisy Duan
Assistant Professor
Johns Hopkins University School of Medicine
Vsevolod Y. Polotsky
The George Washington University School of Medicine and Health SCiences
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