Leo Carlin

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Senior Lecturer

University of Glasgow

United Kingdom

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About

Dr. Leo Carlin is a Senior Lecturer at the University of Glasgow, UK. His research primarily focuses on cancer biology, particularly in the areas of liver cancer, neutrophil recruitment, and the interactions between cancer-associated fibroblasts and endothelial cells. Dr. Carlin's recent articles delve into precision therapy for liver cancer, the impacts of extracellular matrices in cancer progression, and the role of cytokines in metastasis.

Recent Grants

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Evaluation of metabotropic glutamate receptor 3 as a therapeutic target in breast cancer

Open Date: 2019-08-01

Close Date: 2022-07-31

Grant: Close

Regulation of IL-17-producing γδ T cells in breast cancer metastasis

Open Date: 2019-05-01

Close Date: 2022-04-30

Grant: Close

Leukocyte Dynamics

Open Date: 2016-09-01

Close Date: 2023-08-31

Grant: Close

Regulation of Pulmonary Neutrophils In Vivo: Direct Interrogation by Intravital Microscopy

Open Date: 2015-02-01

Close Date: 2017-01-31

Articles (19)

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2021

Collaborators (20)

Rachel Lennon

The University of Manchester

UNITED KINGDOM

Leo Carlin

Research Interests

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About

Recent Grants

Articles (19)

Human-correlated genetic models identify precision therapy for liver cancer

Multimodal decoding of human liver regeneration

Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression

The eATP/P2×7R Axis Drives Quantum Dot-Nanoparticle Induced Neutrophil Recruitment in the Pulmonary Microcirculation.

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function.

Characterizing Neutrophil Subtypes in Cancer Using scRNA Sequencing Demonstrates the Importance of IL1β/CXCR2 Axis in Generation of Metastasis-specific Neutrophils.

Asbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma.

eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation.

Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis.

Omentum-derived matrix enables the study of metastatic ovarian cancer and stromal cell functions in a physiologically relevant environment.

Lung extracellular matrix modulates KRT5<sup>+</sup> basal cell activity in pulmonary fibrosis.

CXCR2 inhibition enables NASH-HCC immunotherapy.

A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair.

“Mind the GAP”: RGS1 hinders antitumor lymphocytes

Analysis of Prostate Cancer Tumor Microenvironment Identifies Reduced Stromal CD4 Effector T-cell Infiltration in Tumors with Pelvic Nodal Metastasis.

Lung Marginated and Splenic Murine Resident Neutrophils Constitute Pioneers in Tissue-Defense During Systemic E. coli Challenge

Metastasis-associated macrophages constrain antitumor capability of natural killer cells in the metastatic site at least partially by membrane bound transforming growth factor β

Neutrophil dynamics in the tumor microenvironment

Collaborators (20)

Rachel Lennon

Edward Roberts

jack leslie

Gareth-Rhys Jones

Maryline Fresquet

David Lewis

Louise Dutton

Stephanie May

Danny Huang

Prakash Ramachandran

Takanori Kitamura

Gaurav Malviya

Daniel Murphy

Thomas Bird

Imran Ahmad

Carsten Gram Hansen

david berman

Demi Brownlie

Vincenzo Ruscica

Josep M Llovet

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