Leonardo Collado-Torres

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Assistant Professor

Johns Hopkins University

United States

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Leonardo Collado-Torres is an Assistant Professor at Johns Hopkins University in the United States. His research primarily focuses on gene expression analysis, systems biology, and the cellular and molecular mechanisms underlying major neurological conditions such as depression and PTSD. He has recently published articles on topics including cell composition estimation in heterogeneous tissue, splicing accuracy across various biological contexts, and the gene expression landscape of the human locus coeruleus.

Recent Grants

Grant: Open

Understanding Schizophrenia Risk Mechanisms Via Multimodal Analysis of Patient-derived Neurons and 3D Cortical Organoids and Correlation with Clinical and Cognitive Phenotypes

Open Date: 2024-08-07

Close Date: 2029-04-30

Grant: Close

1/2 Large-scale, single-cell characterization of molecular and cellular networks of mood regulation circuitry in major depressive disorder

Open Date: 2023-01-01

Close Date: 2024-08-31

Grant: Open

Regulation of Gene Expression in the Human Habenula in Comorbid Opioid Addiction and Depression

Open Date: 2022-07-01

Close Date: 2027-04-30

Grant: Close

Registration of spatial gene expression in key nodes of reward-related circuitry in the human brain

Open Date: 2021-09-30

Close Date: 2026-07-31

Grant: Close

Laminar dissection of cortical human brain gene expression in neuropsychiatric disorders

Open Date: 2021-06-23

Close Date: 2026-03-31

Articles (10)

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2025

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2025

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2025

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2024

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2024

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2024

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2024

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2023

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2023

Collaborators (6)

Zhongbo Chen

UNITED KINGDOM

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Alexis Papariello

Research Assistant Professor

East Carolina University

UNITED STATES

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Juan A. Botía

University College London

UNITED KINGDOM

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Marie Bækvad-Hansen

Statens Serum Institut

DENMARK

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Andrew Jaffe

Neumora Therapeutics

UNITED STATES

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Charles Nemeroff

Matthew P. Nemeroff Chair, Director Institute for Early Life Adversity Research, Professor

The University of Texas at Austin Dell Medical School

UNITED STATES

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Leonardo Collado-Torres

Research Interests

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About

Recent Grants

Articles (10)

lute: estimating the cell composition of heterogeneous tissue with varying cell sizes using gene expression.

Large-scale transcriptomic analyses of major depressive disorder reveal convergent dysregulation of synaptic pathways in excitatory neurons.

Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation.

Splicing accuracy varies across human introns, tissues, age and disease.

Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood

Integrating gene expression and imaging data across Visium capture areas with visiumStitched.

The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics.

TrkB-dependent regulation of molecular signaling across septal cell types.

Challenges and opportunities to computationally deconvolve heterogeneous tissue with varying cell sizes using single-cell RNA-sequencing datasets.

Data-driven identification of total RNA expression genes for estimation of RNA abundance in heterogeneous cell types highlighted in brain tissue

Collaborators (6)

Zhongbo Chen

Alexis Papariello

Juan A. Botía

Marie Bækvad-Hansen

Andrew Jaffe

Charles Nemeroff

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