Leonardo Ferreira

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Assistant Professor

Medical University of South Carolina

United States

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About

Dr. Leonardo Ferreira is an Assistant Professor at the Medical University of South Carolina, USA. His research focuses on the interplay between nutrition and gut microbiota with the immune system, chimeric antigen receptor (CAR) technology, and the development of regulatory T cells. Recent publications include investigations into chronic disease mechanisms, CAR T cell therapy in solid tumors, and the remodeling of the maternal-fetal interface.

Recent Grants

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Repurposing chimeric antigen receptor regulatory T cells to eradicate solid tumors

Open Date: 2023-04-01

Close Date: 2024-03-01

Grant: Close

Rapid, single-step precision engineering and pre-clinical evaluation of chimeric antigen receptor Regulatory T cells for Type 1 diabetes

Open Date: 2022-07-01

Close Date: 2023-06-30

Grant: Close

Co-engineering stem cell-derived beta cells and regulatory T cells for type 1 diabetes

Open Date: 2022-04-01

Close Date: 2023-03-01

Grant: Close

Engineering regulatory T cells as living drugs for type 1 diabetes

Open Date: 2022-04-01

Close Date: 2023-03-01

Grant: Close

Engineering human regulatory T cells to protect human pancreatic islets from immune attack

Open Date: 2022-04-01

Close Date: 2023-03-01

Articles (18)

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2021

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2021

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2021

Collaborators (5)

Richard ONeil

Medical University of South Carolina

UNITED STATES

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Laurent Perez

Professeur associé

Université de Lausanne Faculté de biologie et de médecine

SWITZERLAND

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Mohsen Khosravi Maharlooei

Assistant Professor

Mayo Clinic Arizona

UNITED STATES

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Justin Eyquem

Assistant Professor

University of California, San Francisco

UNITED STATES

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Bowen Gu

Harvard University

UNITED STATES

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Leonardo Ferreira

Research Interests

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About

Recent Grants

Articles (18)

Nutrition and Gut Microbiota–Immune System Interplay in Chronic Diseases

Expanding the engineered Treg multiverse

Generation of Human Chimeric Antigen Receptor Regulatory T Cells.

Progesterone-mediated remodeling of the maternal-fetal interface by a PGRMC1-dependent mechanism

How to Test Human CAR T Cells in Solid Tumors, the Next Frontier of CAR T Cell Therapy.

Redirecting Human Conventional and Regulatory T Cells Using Chimeric Antigen Receptors.

High-affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells

Combinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cells

Efficient T cell adoptive transfer in lymphoreplete hosts mediated by transient activation of Stat5 signaling.

Conference report: Advanced Therapies Week 2023

Regulatory T cell homeostasis: Requisite signals and implications for clinical development of biologics.

The emerging role of regulatory cell-based therapy in autoimmune disease.

The dichotomous outcomes of TNFα signaling in CD4<sup>+</sup> T cells.

The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28.

IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function.

Modeling human T1D-associated autoimmune processes.

CAR T-Cell Therapy: Is CD28-CAR Heterodimerization Its Achilles' Heel?

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance.

Collaborators (5)

Richard ONeil

Laurent Perez

Mohsen Khosravi Maharlooei

Justin Eyquem

Bowen Gu

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