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Leonardo SORCI

Associate Professor

Marche Polytechnic University

Italy

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Research Interests

Biochemistry

100%

Biochemical Engineering

40%

Metabolic Biology

40%

Enzyme Engineering

30%

Molecular Biology

20%

Heterocyclic Chemistry

20%

Allosteric Regulation

20%

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Articles14

Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes

Article Link

Year:

2024

Periplasmic binding proteins Bug69 and Bug27 from Bordetella pertussis are in vitro high-affinity quinolinate binders with a potential role in NAD biosynthesis

Article Link

Year:

2024

Probing conformational dynamics of EGFR mutants via SEIRA spectroscopy: potential implications for tyrosine kinase inhibitor design

Article Link

Year:

2024

A Versatile Continuous Fluorometric Enzymatic Assay for Targeting Nicotinate Phosphoribosyltransferase

Article Link

Year:

2023

Properly Substituted Benzimidazoles as a New Promising Class of Nicotinate Phosphoribosyltransferase (NAPRT) Modulators

Article Link

Year:

2023

Molecular insights into the interaction between human nicotinamide phosphoribosyltransferase and Toll-like receptor 4

Article Link

Year:

2022

Bacterial NadQ (COG4111) is a Nudix-like, ATP-responsive regulator of NAD biosynthesis

Article Link

Year:

2022

Identification of a novel nitroflavone-based scaffold for designing mutant-selective EGFR tyrosine kinase inhibitors targeting T790M and C797S resistance in advanced NSCLC

Article Link

Year:

2022

Mechanistic insight toward EGFR activation induced by ATP: role of mutations and water in ATP binding patterns

Article Link

Year:

2022

Enzymology of extracellular NAD metabolism.

Article Link

Year:

2021

Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells.

Article Link

Year:

2020

The Prospective Synergy of Antitubercular Drugs With NAD Biosynthesis Inhibitors.

Article Link

Year:

2020

Functional characterization of COG1713 (YqeK) as a novel diadenosine tetraphosphate hydrolase family

Article Link

Year:

2020

Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival

Article Link

Year:

2020

Collaborators18

Giacomo Corleone

ITALY

Loredana CAPPELLACCI

Associate Professor

University of Camerino

ITALY

Esther Kellenberger

FRANCE

Nadia RAFFAELLI

Marche Polytechnic University

ITALY

Stefano Amatori

Assistant Professor

University of Urbino Carlo Bo

ITALY

Valentina Audrito

Università degli Studi del Piemonte Orientale Amedeo Avogadro

ITALY

Michele Cianci

Associate Professor

Università Politecnica delle Marche

ITALY

Fabio Del Bello

University of Camerino

ITALY

Vladia Monsurrò

University of Verona

ITALY

Roberta Galeazzi

Università Politecnica delle Marche

ITALY

Michele Guescini

University of Urbino Carlo Bo

ITALY

Laura Graciotti

Professor

Marche Polytechnic University

ITALY

Emiliano Laudadio

ITALY

Giuseppe Orsomando

Marche Polytechnic University

ITALY

Gianfabio Giorgioni

Assistant Professor

University of Camerino

ITALY

Riccardo Petrelli

University of Camerino

ITALY

Cristina Minnelli

Marche Polytechnic University

ITALY

Santina Bruzzone

Associate Professor of Biochemistry

University of Genoa

ITALY

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Leonardo SORCI

Associate Professor

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Research Interests

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Articles14

Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes

Periplasmic binding proteins Bug69 and Bug27 from <i>Bordetella pertussis</i> are <i>in vitro</i> high-affinity quinolinate binders with a potential role in NAD biosynthesis

Probing conformational dynamics of EGFR mutants <i>via</i> SEIRA spectroscopy: potential implications for tyrosine kinase inhibitor design

A Versatile Continuous Fluorometric Enzymatic Assay for Targeting Nicotinate Phosphoribosyltransferase

Properly Substituted Benzimidazoles as a New Promising Class of Nicotinate Phosphoribosyltransferase (NAPRT) Modulators

Molecular insights into the interaction between human nicotinamide phosphoribosyltransferase and Toll-like receptor 4

Bacterial NadQ (COG4111) is a Nudix-like, ATP-responsive regulator of NAD biosynthesis

Identification of a novel nitroflavone-based scaffold for designing mutant-selective EGFR tyrosine kinase inhibitors targeting T790M and C797S resistance in advanced NSCLC

Mechanistic insight toward EGFR activation induced by ATP: role of mutations and water in ATP binding patterns

Enzymology of extracellular NAD metabolism.

Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells.

The Prospective Synergy of Antitubercular Drugs With NAD Biosynthesis Inhibitors.

Functional characterization of COG1713 (YqeK) as a novel diadenosine tetraphosphate hydrolase family

Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival

Collaborators18

Giacomo Corleone

Loredana CAPPELLACCI

Esther Kellenberger

Nadia RAFFAELLI

Stefano Amatori

Valentina Audrito

Michele Cianci

Fabio Del Bello

Vladia Monsurrò

Roberta Galeazzi

Michele Guescini

Laura Graciotti

Emiliano Laudadio

Giuseppe Orsomando

Gianfabio Giorgioni

Riccardo Petrelli

Cristina Minnelli

Santina Bruzzone

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