leslie goo

Assistant Professor

Fred Hutch Cancer Center

United States

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About

Leslie Goo is an Assistant Professor at the Fred Hutch Cancer Center in the United States. His research focuses on the functional genomics of flavivirus infections, particularly investigating the roles of specific proteins in antibody-dependent enhancement mechanisms and the impacts of mutations in viral envelope proteins on antibody sensitivity. Recent publications highlight his work on broadly neutralizing antibodies against flaviviruses, contributing significantly to the understanding of dengue and Zika virus dynamics.

Articles (6)

Year:

2024

Year:

2024

Year:

2023

Year:

2023

Year:

2021

Year:

2020

Collaborators (1)

Jesse Bloom

Fred Hutchinson Cancer Research Center

UNITED STATES

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leslie goo

Research Interests

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Articles (6)

Defining the impact of flavivirus envelope protein glycosylation site mutations on sensitivity to broadly neutralizing antibodies

Functional genomics screens reveal a role for TBC1D24 and SV2B in antibody-dependent enhancement of dengue virus infection

The effect of single mutations in Zika virus envelope on escape from broadly neutralizing antibodies

Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses

Dengue Virus Serotype 1 Conformational Dynamics Confers Virus Strain-Dependent Patterns of Neutralization by Polyclonal Sera.

A (class-)switch in the antibody response may distinguish primary from secondary dengue virus infection.

Collaborators (1)

Jesse Bloom

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