Leslie Shaw

Professor

University of Massachusetts Chan Medical School

United States

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Dr. Leslie Shaw is a Professor at the University of Massachusetts Chan Medical School in the United States. Her research focuses on the insulin and IGF signaling pathways in breast cancer, particularly regarding their roles in cancer stem cell regulation and therapeutic implications. Recent publications include studies on IRS2 dynamics, MYC regulation, and selenium detoxification in cancer cells.

Articles (5)

Year:

2024

Year:

2022

Year:

2022

Year:

2021

Year:

2020

Collaborators (1)

Namgyu Lee

University of Massachusetts Chan Medical School

UNITED STATES

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Leslie Shaw

Research Interests

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Articles (5)

Fluorescent tagging of endogenous IRS2 with an auxin-dependent degron to assess dynamic intracellular localization and function.

The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC.

The Insulin-like Growth Factor Signaling Pathway in Breast Cancer: An Elusive Therapeutic Target.

Diversity of insulin and IGF signaling in breast cancer: Implications for therapy.

Selenium detoxification is required for cancer-cell survival.

Collaborators (1)

Namgyu Lee

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