Lhassane Ismaili

Professeur

Université de Franche-Comté

France

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About

Prof. Lhassane Ismaili is a faculty member at Université de Franche-Comté in France. His research primarily focuses on the discovery and synthesis of novel compounds for therapeutic applications, including treatments for Alzheimer's disease and cancer. Recent studies include the development of potential neuroprotective agents and multitargeted ligands that engage with calcium channels and other biological pathways.

Articles (16)

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2022

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2021

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2021

Collaborators (13)

Patrick Dallemagne

Professor CEx2

Université de Caen Normandie

FRANCE

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hélène MARTIN

Université de Franche-Comté

FRANCE

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Kinga Sałat

profesor nadzwyczajny/prof. dr hab.

Uniwersytet Jagiellonski Collegium Medicum

POLAND

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Krzysztof Jozwiak

Medical University of Lublin

POLAND

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DANIEL GONZALEZ NIETO

Universidad Politécnica de Madrid

SPAIN

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Artur Wnorowski

Assistant Professor

Medical University of Lublin

POLAND

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Audrey DAVIS

Université de Caen Normandie

FRANCE

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Isabel Iriepa

Universidad de Alcalá

SPAIN

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Arnaud Béduneau

Université de Franche-Comté

FRANCE

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Lhassane Idoumghar

FRANCE

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christophe rochais

Professor

Université de Caen Normandie

FRANCE

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Céline Demougeot

Université de Franche-Comté

FRANCE

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Carine Van Lint

Université libre de Bruxelles (ULB)

BELGIUM

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Lhassane Ismaili

Research Interests

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Articles (16)

Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties

Synthesis and Biological Evaluation of New Benzochromenopyrimidines for the Therapy of Colon and Lung Cancer

Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors

Efficient Two-Step Synthesis of Novel Pyrimido[4,5-d] Pyrimidines with Potent Neuroprotective, Antioxidant, and Aβ Anti-Aggregation Properties

The Proof-of-Concept of MBA121, a Tacrine–Ferulic Acid Hybrid, for Alzheimer’s Disease Therapy

Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer’s Disease Treatment

Calcium channel blockers’ contribution to overcoming Current drug discovery challenges in Alzheimer’s disease

Design, Synthesis, <i>in Silico</i> and Biological Evaluation of Novel 4‐Aminopyrimidine‐5‐carbonitriles

Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca<sup>2+</sup> Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

Ferulic acid derivatives block coronaviruses HCoV-229E and SARS-CoV-2 replication in vitro

Benzochromenopyrimidines: Synthesis, Antiproliferative Activity against Colorectal Cancer and Physicochemical Properties

Multicomponent reactions as a privileged tool for multitarget-directed ligand strategies in Alzheimer’s disease therapy

Editorial: Advances in drug discovery for anti-Alzheimer’s agents

Latest progress in the development of multitarget ligands for Alzheimer's disease based on the Hantzsch reaction

Synthesis and Biological Assessment of PyrimidoTacrines as Promising Agents for Alzheimer's Disease Therapy

Synthesis of new Hantzsch adducts showing Ca2+ channel blockade capacity, cholinesterase inhibition and antioxidant power

Collaborators (13)

Patrick Dallemagne

hélène MARTIN

Kinga Sałat

Krzysztof Jozwiak

DANIEL GONZALEZ NIETO

Artur Wnorowski

Audrey DAVIS

Isabel Iriepa

Arnaud Béduneau

Lhassane Idoumghar

christophe rochais

Céline Demougeot

Carine Van Lint

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