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Lhassane Ismaili

Professeur

Université de Franche-Comté

France

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Research Interests

Pharmaceutical Chemistry

100%

Organic Chemistry

70%

Natural Product Synthesis

50%

Neuropharmacology

50%

Chemical Biology

50%

Ligand Chemistry

40%

Heterocyclic Chemistry

40%

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Articles16

Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties

Article Link

Year:

2024

Synthesis and Biological Evaluation of New Benzochromenopyrimidines for the Therapy of Colon and Lung Cancer

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Year:

2024

Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors

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Year:

2024

Efficient Two-Step Synthesis of Novel Pyrimido[4,5-d] Pyrimidines with Potent Neuroprotective, Antioxidant, and Aβ Anti-Aggregation Properties

Article Link

Year:

2024

The Proof-of-Concept of MBA121, a Tacrine–Ferulic Acid Hybrid, for Alzheimer’s Disease Therapy

Article Link

Year:

2023

Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer’s Disease Treatment

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Year:

2023

Calcium channel blockers’ contribution to overcoming Current drug discovery challenges in Alzheimer’s disease

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Year:

2023

Design, Synthesis, <i>in Silico</i> and Biological Evaluation of Novel 4‐Aminopyrimidine‐5‐carbonitriles

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Year:

2023

Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca<sup>2+</sup> Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

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Year:

2022

Ferulic acid derivatives block coronaviruses HCoV-229E and SARS-CoV-2 replication in vitro

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Year:

2022

Benzochromenopyrimidines: Synthesis, Antiproliferative Activity against Colorectal Cancer and Physicochemical Properties

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Year:

2022

Multicomponent reactions as a privileged tool for multitarget-directed ligand strategies in Alzheimer’s disease therapy

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Year:

2022

Editorial: Advances in drug discovery for anti-Alzheimer’s agents

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Year:

2022

Latest progress in the development of multitarget ligands for Alzheimer's disease based on the Hantzsch reaction

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Year:

2022

Synthesis and Biological Assessment of PyrimidoTacrines as Promising Agents for Alzheimer's Disease Therapy

Article Link

Year:

2021

Synthesis of new Hantzsch adducts showing Ca2+ channel blockade capacity, cholinesterase inhibition and antioxidant power

Article Link

Year:

2021

Collaborators13

Patrick Dallemagne

Professor CEx2

Université de Caen Normandie

FRANCE

hélène MARTIN

Université de Franche-Comté

FRANCE

Kinga Sałat

profesor nadzwyczajny/prof. dr hab.

Uniwersytet Jagiellonski Collegium Medicum

POLAND

Krzysztof Jozwiak

Medical University of Lublin

POLAND

DANIEL GONZALEZ NIETO

Universidad Politécnica de Madrid

SPAIN

Artur Wnorowski

Assistant Professor

Medical University of Lublin

POLAND

Audrey DAVIS

Université de Caen Normandie

FRANCE

Isabel Iriepa

Universidad de Alcalá

SPAIN

Arnaud Béduneau

Université de Franche-Comté

FRANCE

Lhassane Idoumghar

FRANCE

christophe rochais

Professor

Université de Caen Normandie

FRANCE

Céline Demougeot

Université de Franche-Comté

FRANCE

Carine Van Lint

Université libre de Bruxelles (ULB)

BELGIUM

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