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Li Shen

Professor of Informatics

University of Pennsylvania

United States

Has grant

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Research Interests

Neuropsychology

70%

Cognitive Neuroscience

80%

Alzheimer's Disease

50%

Cognitive Impairment

50%

Neuroimaging

40%

Neurodegenerative Disease

40%

Neuroscience

40%

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Recent Grants

Grant: Close

Translational big data analytic approaches to advance drug repurposing for Alzheimer's disease

Open Date: 2021-05-01

Close Date: 2026-04-30

Grant: Close

Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease Biobanks

Open Date: 2020-09-15

Close Date: 2025-08-31

Grant: Close

Informatics Algorithms for Genomic Analysis of Brain Imaging Data

Open Date: 2020-07-01

Close Date: 2024-03-31

Grant: Close

BIGDATA: IA: Collaborative Research: Asynchronous Distributed Machine Learning Framework for Multi-Site Collaborative Brain Big Data Mining

Open Date: 2019-01-01

Close Date: 2022-12-31

Grant: Close

SCH: INT: Mining Drug-Drug Interaction Induced Adverse Effects from Health Record Databases

Open Date: 2016-09-01

Close Date: 2020-08-31

Articles26

Subject-adaptive meta-learning for personalized BCI: A fusion of resting-state EEG signal and task-specific information

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Year:

2026

Establishing group-level brain structural connectivity incorporating anatomical knowledge under latent space modeling

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Year:

2025

S‐GMAS: Genome‐Wide Mediation Analysis With Brain Subcortical Shape Mediators

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2025

MG-TCCA: Tensor Canonical Correlation Analysis Across Multiple Groups

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2025

SDoH-GPT: using large language models to extract social determinants of health

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2025

Predicting explainable dementia types with LLM-aided feature engineering

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2025

High-dimensional mediation analysis reveals the mediating role of physical activity patterns in genetic pathways leading to AD-like brain atrophy.

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2025

Multi-Modal Diagnosis of Alzheimer’s Disease using Interpretable Graph Convolutional Networks

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2024

Incorporating graph information in Bayesian factor analysis with robust and adaptive shrinkage priors

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2024

Identifying Progression-Specific Alzheimer’s Subtypes Using Multimodal Transformer

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2024

Distance-weighted Sinkhorn loss for Alzheimer’s disease classification

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2024

Homological Landscape of Human Brain Functional Sub-Circuits

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2024

Sex modifies effects of imaging and CSF biomarkers on cognitive and functional outcomes: a study of Alzheimer's disease

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2024

Repurposing FDA-Approved Drugs Against Potential Drug Targets Involved in Brain Inflammation Contributing to Alzheimer’s Disease

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2024

QOT: Quantized Optimal Transport for sample-level distance matrix in single-cell omics

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2024

Genome-Wide Association Analysis across Endophenotypes in Alzheimer’s Disease: Main Effects and Disease Stage-Specific Interactions

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2023

Identifying Alzheimer’s genes via brain transcriptome mapping

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Year:

2022

Identifying genetic markers enriched by brain imaging endophenotypes in Alzheimer’s disease

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2022

Integrative analysis of summary data from GWAS and eQTL studies implicates genes differentially expressed in Alzheimer’s disease

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2022

Deep multiview learning to identify imaging-driven subtypes in mild cognitive impairment

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2022

Identifying genes associated with brain volumetric differences through tissue specific transcriptomic inference from GWAS summary data

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2022

Mining High-Level Imaging Genetic Associations via Clustering AD Candidate Variants with Similar Brain Association Patterns

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2022

Improved Prediction of Cognitive Outcomes via Globally Aligned Imaging Biomarker Enrichments Over Progressions

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2021

Progress and Research Priorities in Imaging Genomics for Heart and Lung Disease: Summary of an NHLBI Workshop

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Year:

2021

Identify Consistent Cross-Modality Imaging Genetic Patterns via Discriminant Sparse Canonical Correlation Analysis

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Year:

2021

A structural enriched functional network: An application to predict brain cognitive performance

Article Link

Year:

2021

Collaborators13

Haoyang Wang

Teaching Assistant

University of Texas at Austin

UNITED STATES

Selena Wang

Assistant Professor

Indiana University School of Medicine

UNITED STATES

Richard Nowakowski

Professor and Chair

Florida State University

UNITED STATES

Andrew Saykin

Professor and Director, Center for Neuroimaging and Indiana Alzheimer's Disease Research Center

Indiana University School of Medicine

UNITED STATES

Mansu Kim

Assistant Professor

Gwangju Institute of Science and Technology

SOUTH KOREA

Diego Machado Reyes

Rensselaer Polytechnic Institute

UNITED STATES

Juergen Hahn

Professor

Rensselaer Polytechnic Institute

UNITED STATES

Hua Wang

Professor

Colorado School of Mines

UNITED STATES

Matthew Nayor

Boston University School of Medicine

UNITED STATES

Qi Long

Professor

University of Pennsylvania

UNITED STATES

Lifang He

Assistant Professor

Lehigh University

UNITED STATES

CHANGGEE CHANG

Assistant Professor

Indiana University School of Medicine

UNITED STATES

Mary Regina Boland

Assistant Professor

University of Pennsylvania

UNITED STATES

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